Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Anti-androgen therapy inhibits prostate cancer (PC) progression, and is thought to act directly on cancer cells. Here the authors show that androgen receptor is expressed on normal and PC-associated macrophages, and its stimulation alters macrophage secretome to promote migration of cultured PC cell...

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Autores principales: Bianca Cioni, Anniek Zaalberg, Judy R. van Beijnum, Monique H. M. Melis, Johan van Burgsteden, Mauro J. Muraro, Erik Hooijberg, Dennis Peters, Ingrid Hofland, Yoni Lubeck, Jeroen de Jong, Joyce Sanders, Judith Vivié, Henk G. van der Poel, Jan Paul de Boer, Arjan W. Griffioen, Wilbert Zwart, Andries M. Bergman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/3be95a4024404f56acd7fe8a4155f96c
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spelling oai:doaj.org-article:3be95a4024404f56acd7fe8a4155f96c2021-12-02T17:42:05ZAndrogen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion10.1038/s41467-020-18313-y2041-1723https://doaj.org/article/3be95a4024404f56acd7fe8a4155f96c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18313-yhttps://doaj.org/toc/2041-1723Anti-androgen therapy inhibits prostate cancer (PC) progression, and is thought to act directly on cancer cells. Here the authors show that androgen receptor is expressed on normal and PC-associated macrophages, and its stimulation alters macrophage secretome to promote migration of cultured PC cell lines.Bianca CioniAnniek ZaalbergJudy R. van BeijnumMonique H. M. MelisJohan van BurgstedenMauro J. MuraroErik HooijbergDennis PetersIngrid HoflandYoni LubeckJeroen de JongJoyce SandersJudith ViviéHenk G. van der PoelJan Paul de BoerArjan W. GriffioenWilbert ZwartAndries M. BergmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bianca Cioni
Anniek Zaalberg
Judy R. van Beijnum
Monique H. M. Melis
Johan van Burgsteden
Mauro J. Muraro
Erik Hooijberg
Dennis Peters
Ingrid Hofland
Yoni Lubeck
Jeroen de Jong
Joyce Sanders
Judith Vivié
Henk G. van der Poel
Jan Paul de Boer
Arjan W. Griffioen
Wilbert Zwart
Andries M. Bergman
Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
description Anti-androgen therapy inhibits prostate cancer (PC) progression, and is thought to act directly on cancer cells. Here the authors show that androgen receptor is expressed on normal and PC-associated macrophages, and its stimulation alters macrophage secretome to promote migration of cultured PC cell lines.
format article
author Bianca Cioni
Anniek Zaalberg
Judy R. van Beijnum
Monique H. M. Melis
Johan van Burgsteden
Mauro J. Muraro
Erik Hooijberg
Dennis Peters
Ingrid Hofland
Yoni Lubeck
Jeroen de Jong
Joyce Sanders
Judith Vivié
Henk G. van der Poel
Jan Paul de Boer
Arjan W. Griffioen
Wilbert Zwart
Andries M. Bergman
author_facet Bianca Cioni
Anniek Zaalberg
Judy R. van Beijnum
Monique H. M. Melis
Johan van Burgsteden
Mauro J. Muraro
Erik Hooijberg
Dennis Peters
Ingrid Hofland
Yoni Lubeck
Jeroen de Jong
Joyce Sanders
Judith Vivié
Henk G. van der Poel
Jan Paul de Boer
Arjan W. Griffioen
Wilbert Zwart
Andries M. Bergman
author_sort Bianca Cioni
title Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
title_short Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
title_full Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
title_fullStr Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
title_full_unstemmed Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
title_sort androgen receptor signalling in macrophages promotes trem-1-mediated prostate cancer cell line migration and invasion
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3be95a4024404f56acd7fe8a4155f96c
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