Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy

Gas therapy has received widespread attention from the medical community as an emerging and promising therapeutic approach to cancer treatment. Among all gas molecules, nitric oxide (NO) was the first one to be applied in the biomedical field for its intriguing properties and unique anti-tumor mecha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yijun Zhao, Xumei Ouyang, Yongjun Peng, Shaojun Peng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gas therapy stimuli responsive drug delivery nanomedicine nitric oxide Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3beeaba721bf4d6887a488df6ec94e44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3beeaba721bf4d6887a488df6ec94e44
record_format	dspace
spelling	oai:doaj.org-article:3beeaba721bf4d6887a488df6ec94e442021-11-25T18:41:48ZStimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy10.3390/pharmaceutics131119171999-4923https://doaj.org/article/3beeaba721bf4d6887a488df6ec94e442021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1917https://doaj.org/toc/1999-4923Gas therapy has received widespread attention from the medical community as an emerging and promising therapeutic approach to cancer treatment. Among all gas molecules, nitric oxide (NO) was the first one to be applied in the biomedical field for its intriguing properties and unique anti-tumor mechanisms which have become a research hotspot in recent years. Despite the great progress of NO in cancer therapy, the non-specific distribution of NO in vivo and its side effects on normal tissue at high concentrations have impaired its clinical application. Therefore, it is important to develop facile NO-based nanomedicines to achieve the on-demand release of NO in tumor tissue while avoiding the leakage of NO in normal tissue, which could enhance therapeutic efficacy and reduce side effects at the same time. In recent years, numerous studies have reported the design and development of NO-based nanomedicines which were triggered by exogenous stimulus (light, ultrasound, X-ray) or tumor endogenous signals (glutathione, weak acid, glucose). In this review, we summarized the design principles and release behaviors of NO-based nanomedicines upon various stimuli and their applications in synergistic cancer therapy. We also discuss the anti-tumor mechanisms of NO-based nanomedicines in vivo for enhanced cancer therapy. Moreover, we discuss the existing challenges and further perspectives in this field in the aim of furthering its development.Yijun ZhaoXumei OuyangYongjun PengShaojun PengMDPI AGarticlegas therapystimuli responsivedrug deliverynanomedicinenitric oxidePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1917, p 1917 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gas therapy stimuli responsive drug delivery nanomedicine nitric oxide Pharmacy and materia medica RS1-441
spellingShingle	gas therapy stimuli responsive drug delivery nanomedicine nitric oxide Pharmacy and materia medica RS1-441 Yijun Zhao Xumei Ouyang Yongjun Peng Shaojun Peng Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
description	Gas therapy has received widespread attention from the medical community as an emerging and promising therapeutic approach to cancer treatment. Among all gas molecules, nitric oxide (NO) was the first one to be applied in the biomedical field for its intriguing properties and unique anti-tumor mechanisms which have become a research hotspot in recent years. Despite the great progress of NO in cancer therapy, the non-specific distribution of NO in vivo and its side effects on normal tissue at high concentrations have impaired its clinical application. Therefore, it is important to develop facile NO-based nanomedicines to achieve the on-demand release of NO in tumor tissue while avoiding the leakage of NO in normal tissue, which could enhance therapeutic efficacy and reduce side effects at the same time. In recent years, numerous studies have reported the design and development of NO-based nanomedicines which were triggered by exogenous stimulus (light, ultrasound, X-ray) or tumor endogenous signals (glutathione, weak acid, glucose). In this review, we summarized the design principles and release behaviors of NO-based nanomedicines upon various stimuli and their applications in synergistic cancer therapy. We also discuss the anti-tumor mechanisms of NO-based nanomedicines in vivo for enhanced cancer therapy. Moreover, we discuss the existing challenges and further perspectives in this field in the aim of furthering its development.
format	article
author	Yijun Zhao Xumei Ouyang Yongjun Peng Shaojun Peng
author_facet	Yijun Zhao Xumei Ouyang Yongjun Peng Shaojun Peng
author_sort	Yijun Zhao
title	Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
title_short	Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
title_full	Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
title_fullStr	Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
title_full_unstemmed	Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
title_sort	stimuli responsive nitric oxide-based nanomedicine for synergistic therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3beeaba721bf4d6887a488df6ec94e44
work_keys_str_mv	AT yijunzhao stimuliresponsivenitricoxidebasednanomedicineforsynergistictherapy AT xumeiouyang stimuliresponsivenitricoxidebasednanomedicineforsynergistictherapy AT yongjunpeng stimuliresponsivenitricoxidebasednanomedicineforsynergistictherapy AT shaojunpeng stimuliresponsivenitricoxidebasednanomedicineforsynergistictherapy
_version_	1718410765820493824

Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy

Ejemplares similares