Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement

Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.

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Autores principales:	Bo Zhou, Ying-Qi Zhang, Kairui Zhang, Ming-Yang Yang, Yang-Bo Chen, You Li, Qian Peng, Shou-Fei Zhu, Qi-Lin Zhou, Long-Wu Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bf0733c651b4490b0ac9ecc1a0a31bc
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spelling	oai:doaj.org-article:3bf0733c651b4490b0ac9ecc1a0a31bc2021-12-02T15:35:55ZStereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement10.1038/s41467-019-11245-22041-1723https://doaj.org/article/3bf0733c651b4490b0ac9ecc1a0a31bc2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11245-2https://doaj.org/toc/2041-1723Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.Bo ZhouYing-Qi ZhangKairui ZhangMing-Yang YangYang-Bo ChenYou LiQian PengShou-Fei ZhuQi-Lin ZhouLong-Wu YeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
description	Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.
format	article
author	Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye
author_facet	Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye
author_sort	Bo Zhou
title	Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
title_short	Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
title_full	Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
title_fullStr	Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
title_full_unstemmed	Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
title_sort	stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3bf0733c651b4490b0ac9ecc1a0a31bc
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Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement

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