13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis

Background: 'Helicobacter pylori' ('H. pylori') infection is known to be associated with peptic ulcer and gastric cancer. Detection of 'H. pylori' infection is a significant part of peptic ulcer and gastric cancer prevention and management. 13C-urea breath test (UBT) pr...

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Autores principales:	Muhammad Aklil Abd Rahim, Fadzrul Hafiz Johani, Shamsul Azhar Shah, Mohd Rohaizat Hassan, Mohd Rizal Abdul Manaf
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3bf24d1d3511481ca1a3335dbe238a4f
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spelling	oai:doaj.org-article:3bf24d1d3511481ca1a3335dbe238a4f2021-12-02T05:42:06Z13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis2214-999610.5334/aogh.2570https://doaj.org/article/3bf24d1d3511481ca1a3335dbe238a4f2019-07-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2570https://doaj.org/toc/2214-9996Background: 'Helicobacter pylori' ('H. pylori') infection is known to be associated with peptic ulcer and gastric cancer. Detection of 'H. pylori' infection is a significant part of peptic ulcer and gastric cancer prevention and management. 13C-urea breath test (UBT) provides a good option for the pathogen detection due to its accuracy and safety. Objective: This review aims to evaluate the 13C-UBT diagnostic accuracy studies conducted among Asian population and validate its use for the Asian population. Methods: Original articles were systematically searched in PubMed, Scopus, and Google Scholar using the PICOS strategy by applying relevant keywords. Only studies published in English and conducted in Asia were included. Our search returned 276 articles. After assessment, 11 articles which answered our research question and met the criteria set for systematic review and meta-analysis were accepted. A total of 15 study protocols were extracted from the 11 accepted articles. Findings: Majority of the studies were conducted in Hong Kong (six), followed by Taiwan (five), Japan (two), and one each in Singapore and Israel. All studies had used histology as part of its gold standard of reference. All but one study was performed on adult populations. The summary estimate for sensitivity was 97% (95% CI: 96, 98%), and specificity was 96% (95% CI: 95, 97%), with significant heterogeneity between studies. Adjusting for the dose (50 mg) and breath sample collection time (20 minutes) had improved both accuracy estimates and significantly reduced heterogeneity. Conclusion: This review supports the test-and-treat strategy for 'H. pylori' infection management. Prevalence and cost-effectiveness studies are mandatory for health authorities to adopt this strategy into national policy.Muhammad Aklil Abd RahimFadzrul Hafiz JohaniShamsul Azhar ShahMohd Rohaizat HassanMohd Rizal Abdul ManafUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Muhammad Aklil Abd Rahim Fadzrul Hafiz Johani Shamsul Azhar Shah Mohd Rohaizat Hassan Mohd Rizal Abdul Manaf 13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
description	Background: 'Helicobacter pylori' ('H. pylori') infection is known to be associated with peptic ulcer and gastric cancer. Detection of 'H. pylori' infection is a significant part of peptic ulcer and gastric cancer prevention and management. 13C-urea breath test (UBT) provides a good option for the pathogen detection due to its accuracy and safety. Objective: This review aims to evaluate the 13C-UBT diagnostic accuracy studies conducted among Asian population and validate its use for the Asian population. Methods: Original articles were systematically searched in PubMed, Scopus, and Google Scholar using the PICOS strategy by applying relevant keywords. Only studies published in English and conducted in Asia were included. Our search returned 276 articles. After assessment, 11 articles which answered our research question and met the criteria set for systematic review and meta-analysis were accepted. A total of 15 study protocols were extracted from the 11 accepted articles. Findings: Majority of the studies were conducted in Hong Kong (six), followed by Taiwan (five), Japan (two), and one each in Singapore and Israel. All studies had used histology as part of its gold standard of reference. All but one study was performed on adult populations. The summary estimate for sensitivity was 97% (95% CI: 96, 98%), and specificity was 96% (95% CI: 95, 97%), with significant heterogeneity between studies. Adjusting for the dose (50 mg) and breath sample collection time (20 minutes) had improved both accuracy estimates and significantly reduced heterogeneity. Conclusion: This review supports the test-and-treat strategy for 'H. pylori' infection management. Prevalence and cost-effectiveness studies are mandatory for health authorities to adopt this strategy into national policy.
format	article
author	Muhammad Aklil Abd Rahim Fadzrul Hafiz Johani Shamsul Azhar Shah Mohd Rohaizat Hassan Mohd Rizal Abdul Manaf
author_facet	Muhammad Aklil Abd Rahim Fadzrul Hafiz Johani Shamsul Azhar Shah Mohd Rohaizat Hassan Mohd Rizal Abdul Manaf
author_sort	Muhammad Aklil Abd Rahim
title	13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
title_short	13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
title_full	13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
title_fullStr	13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
title_full_unstemmed	13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis
title_sort	13c-urea breath test accuracy for 'helicobacter pylori' infection in the asian population: a meta-analysis
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/3bf24d1d3511481ca1a3335dbe238a4f
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13C-Urea Breath Test Accuracy for 'Helicobacter pylori' Infection in the Asian Population: A Meta-Analysis

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