TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiqui...
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Nature Portfolio
2021
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oai:doaj.org-article:3bf3573d63094261ac7abe05b09d7ee92021-12-02T14:54:28ZTNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth10.1038/s41467-021-25622-32041-1723https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25622-3https://doaj.org/toc/2041-1723The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivoTsz-Yin ChanChristina M. EgbertJulia E. MaxsonAdam SiddiquiLogan J. LarsenKristina KohlerEranga Roshan BalasooriyaKatie L. PenningtonTsz-Ming TsangMadison FreyErik J. SoderblomHuimin GengMarkus MüschenTetyana V. ForostyanSavannah FreeGaelle MercenneCourtney J. BanksJonard ValdozClifford J. WhatcottJason M. FoulksDavid J. BearssThomas O’HareDavid C. S. HuangKenneth A. ChristensenJames MoodySteven L. WarnerJeffrey W. TynerJoshua L. AndersenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tsz-Yin Chan Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| description |
The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo |
| format |
article |
| author |
Tsz-Yin Chan Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen |
| author_facet |
Tsz-Yin Chan Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen |
| author_sort |
Tsz-Yin Chan |
| title |
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| title_short |
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| title_full |
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| title_fullStr |
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| title_full_unstemmed |
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| title_sort |
tnk1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 |
| work_keys_str_mv |
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1718389378242314240 |