Acetylation in Mitochondria Dynamics and Neurodegeneration

Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively moving, dividing, or fusing. This process of mitoc...

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Autores principales:	Jaylyn Waddell, Aditi Banerjee, Tibor Kristian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondria dynamics tubulin acetylation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3bf7250e26d9477ca2981d5b5f5f88f2
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spelling	oai:doaj.org-article:3bf7250e26d9477ca2981d5b5f5f88f22021-11-25T17:10:34ZAcetylation in Mitochondria Dynamics and Neurodegeneration10.3390/cells101130312073-4409https://doaj.org/article/3bf7250e26d9477ca2981d5b5f5f88f22021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3031https://doaj.org/toc/2073-4409Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively moving, dividing, or fusing. This process of mitochondrial dynamics is fine-tuned by a specific group of proteins and their complex post-translational modifications. In this review, we discuss the mitochondrial dynamics regulatory enzymes, their adaptor proteins, and the effect of acetylation on the activity of fusion and fission machinery as a ubiquitous response to metabolic stresses. Further, we discuss the role of intracellular cytoskeleton structures and their post-translational modifications in the modulation of mitochondrial fusion and fission. Finally, we review the role of mitochondrial dynamics dysregulation in the pathophysiology of acute brain injury and the treatment strategies based on modulation of NAD<sup>+</sup>-dependent deacetylation.Jaylyn WaddellAditi BanerjeeTibor KristianMDPI AGarticlemitochondriadynamicstubulinacetylationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3031, p 3031 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria dynamics tubulin acetylation Biology (General) QH301-705.5
spellingShingle	mitochondria dynamics tubulin acetylation Biology (General) QH301-705.5 Jaylyn Waddell Aditi Banerjee Tibor Kristian Acetylation in Mitochondria Dynamics and Neurodegeneration
description	Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively moving, dividing, or fusing. This process of mitochondrial dynamics is fine-tuned by a specific group of proteins and their complex post-translational modifications. In this review, we discuss the mitochondrial dynamics regulatory enzymes, their adaptor proteins, and the effect of acetylation on the activity of fusion and fission machinery as a ubiquitous response to metabolic stresses. Further, we discuss the role of intracellular cytoskeleton structures and their post-translational modifications in the modulation of mitochondrial fusion and fission. Finally, we review the role of mitochondrial dynamics dysregulation in the pathophysiology of acute brain injury and the treatment strategies based on modulation of NAD<sup>+</sup>-dependent deacetylation.
format	article
author	Jaylyn Waddell Aditi Banerjee Tibor Kristian
author_facet	Jaylyn Waddell Aditi Banerjee Tibor Kristian
author_sort	Jaylyn Waddell
title	Acetylation in Mitochondria Dynamics and Neurodegeneration
title_short	Acetylation in Mitochondria Dynamics and Neurodegeneration
title_full	Acetylation in Mitochondria Dynamics and Neurodegeneration
title_fullStr	Acetylation in Mitochondria Dynamics and Neurodegeneration
title_full_unstemmed	Acetylation in Mitochondria Dynamics and Neurodegeneration
title_sort	acetylation in mitochondria dynamics and neurodegeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3bf7250e26d9477ca2981d5b5f5f88f2
work_keys_str_mv	AT jaylynwaddell acetylationinmitochondriadynamicsandneurodegeneration AT aditibanerjee acetylationinmitochondriadynamicsandneurodegeneration AT tiborkristian acetylationinmitochondriadynamicsandneurodegeneration
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Acetylation in Mitochondria Dynamics and Neurodegeneration

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