Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

CP1 is an uropathogenic Escherichia coli previously shown to promote inflammation and progression to prostate cancer. Here the authors show that in the context of a fully developed prostate cancer, CP1 promotes T cell infiltration into the tumour and increases the efficacy of anti-PD1 immunotherapy.

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Autores principales:	Jonathan F. Anker, Anum F. Naseem, Hanlin Mok, Anthony J. Schaeffer, Sarki A. Abdulkadir, Praveen Thumbikat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bf73253b2574b74bdc59f395c2f2af5
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spelling	oai:doaj.org-article:3bf73253b2574b74bdc59f395c2f2af52021-12-02T16:49:36ZMulti-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy10.1038/s41467-018-03900-x2041-1723https://doaj.org/article/3bf73253b2574b74bdc59f395c2f2af52018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03900-xhttps://doaj.org/toc/2041-1723CP1 is an uropathogenic Escherichia coli previously shown to promote inflammation and progression to prostate cancer. Here the authors show that in the context of a fully developed prostate cancer, CP1 promotes T cell infiltration into the tumour and increases the efficacy of anti-PD1 immunotherapy.Jonathan F. AnkerAnum F. NaseemHanlin MokAnthony J. SchaefferSarki A. AbdulkadirPraveen ThumbikatNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan F. Anker Anum F. Naseem Hanlin Mok Anthony J. Schaeffer Sarki A. Abdulkadir Praveen Thumbikat Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
description	CP1 is an uropathogenic Escherichia coli previously shown to promote inflammation and progression to prostate cancer. Here the authors show that in the context of a fully developed prostate cancer, CP1 promotes T cell infiltration into the tumour and increases the efficacy of anti-PD1 immunotherapy.
format	article
author	Jonathan F. Anker Anum F. Naseem Hanlin Mok Anthony J. Schaeffer Sarki A. Abdulkadir Praveen Thumbikat
author_facet	Jonathan F. Anker Anum F. Naseem Hanlin Mok Anthony J. Schaeffer Sarki A. Abdulkadir Praveen Thumbikat
author_sort	Jonathan F. Anker
title	Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
title_short	Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
title_full	Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
title_fullStr	Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
title_full_unstemmed	Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
title_sort	multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3bf73253b2574b74bdc59f395c2f2af5
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Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

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