PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

Abstract Cell-mediated contraction of collagenous matrices is modulated by various growth factors and cytokines, such as platelet-derived growth factor-BB (PDGF-BB). Here we used a genetic cell model to delineate defined signaling pathways that enhance collagen gel contraction downstream of ligand-s...

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Bibliographic Details
Main Authors: Vahid Reyhani, Maria Tsioumpekou, Tijs van Wieringen, Lars Rask, Johan Lennartsson, Kristofer Rubin
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/3bf7f0867e934afa8042fca5e704395d
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