Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)

BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. ...

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Autores principales:	Melany Villegas-Valencia, Libardo Andrés González-Reyes, Helberg Asencio-Santofimio, Jose Oscar Gutierrez-Montes, Angelica García, Silverio Garzón-Gaviria
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2020
Materias:	Zanthoxylum rhoifolium nociception neuromotor effect rotarod test non-polar extract formalin test Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/3bfa6a18223142dab494cf47d4ec1b44
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spelling	oai:doaj.org-article:3bfa6a18223142dab494cf47d4ec1b442021-12-02T18:20:51ZAnalgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)10.17533/udea.vitae.v27n3a030121-40042145-2660https://doaj.org/article/3bfa6a18223142dab494cf47d4ec1b442020-12-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/338956https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. The studies have been limited to the isolation of compounds with antifungal and insecticide activity, using the leaves, branches, and bark of the plant in aqueous, and organic extracts. Neither pharmacological tests have been carried out, nor the analgesic and neuromotor activity have been tested from preparations with this plant’s fruits. OBJECTIVES: To evaluate the analgesic and neuromotor effect of the aqueous and hexane extract of the fruits of Z. rhoifolium. METHODS: As there were no preliminary reports of this study, the first observation was made through Irwin’s test. The formalin and the rotarod test were performed to determine the analgesic and motor coordination effects, respectively. RESULTS: All the evaluated treatments demonstrated to generate analgesia, anesthesia, passivity, reduction in the alarm reaction, and have antinociceptive activity in the formalin test; while only the high dose of the nonpolar extract generated a deficit in the motor performance of the rodents in the rotarod test. CONCLUSIONS: the antinociceptive effect of the aqueous and hexane extracts of this species’ fruits was demonstrated. The hexane extract generated a neuromotor effect, which validates the ethnobotanical reports on Z. rhoifolium fruits. Melany Villegas-ValenciaLibardo Andrés González-ReyesHelberg Asencio-SantofimioJose Oscar Gutierrez-MontesAngelica GarcíaSilverio Garzón-GaviriaUniversidad de AntioquiaarticleZanthoxylum rhoifoliumnociceptionneuromotor effectrotarod testnon-polar extractformalin testFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 27, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zanthoxylum rhoifolium nociception neuromotor effect rotarod test non-polar extract formalin test Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Zanthoxylum rhoifolium nociception neuromotor effect rotarod test non-polar extract formalin test Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
description	BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. The studies have been limited to the isolation of compounds with antifungal and insecticide activity, using the leaves, branches, and bark of the plant in aqueous, and organic extracts. Neither pharmacological tests have been carried out, nor the analgesic and neuromotor activity have been tested from preparations with this plant’s fruits. OBJECTIVES: To evaluate the analgesic and neuromotor effect of the aqueous and hexane extract of the fruits of Z. rhoifolium. METHODS: As there were no preliminary reports of this study, the first observation was made through Irwin’s test. The formalin and the rotarod test were performed to determine the analgesic and motor coordination effects, respectively. RESULTS: All the evaluated treatments demonstrated to generate analgesia, anesthesia, passivity, reduction in the alarm reaction, and have antinociceptive activity in the formalin test; while only the high dose of the nonpolar extract generated a deficit in the motor performance of the rodents in the rotarod test. CONCLUSIONS: the antinociceptive effect of the aqueous and hexane extracts of this species’ fruits was demonstrated. The hexane extract generated a neuromotor effect, which validates the ethnobotanical reports on Z. rhoifolium fruits.
format	article
author	Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria
author_facet	Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria
author_sort	Melany Villegas-Valencia
title	Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
title_short	Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
title_full	Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
title_fullStr	Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
title_full_unstemmed	Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
title_sort	analgesic and neuromotor effects of two extracts of zanthoxylum rhoifolium (rutaceae) in the swiss albino mouse (mus musculus)
publisher	Universidad de Antioquia
publishDate	2020
url	https://doaj.org/article/3bfa6a18223142dab494cf47d4ec1b44
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Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)

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