Systematic review of hormone replacement therapy in the infertile man

Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for h...

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Autores principales:	Amr El Meliegy, Ahmad Motawi, Mohamed Ahmed Abd El Salam
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/3bfadcb20e014c22b7d7aa39dec2411a
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spelling	oai:doaj.org-article:3bfadcb20e014c22b7d7aa39dec2411a2021-12-02T12:36:25ZSystematic review of hormone replacement therapy in the infertile man2090-598X10.1016/j.aju.2017.11.011https://doaj.org/article/3bfadcb20e014c22b7d7aa39dec2411a2018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301456https://doaj.org/toc/2090-598XObjectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age. Materials and methods: We performed a comprehensive literature review for the years 1978–2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed. Review was consistent with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) criteria. We used Medical Subject Heading terms for the search including ‘testosterone replacement therapy’ or ‘TRT’ and ‘male infertility’. Results: In all, 91 manuscripts were screened and the final number used for the review was 56. All studies included were performed in adults, were written in English and had an abstract available. Conclusions: Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. Keywords: Gonadotrophins, Hypogonadism, Infertility, Systematic review, Testosterone therapyAmr El MeliegyAhmad MotawiMohamed Ahmed Abd El SalamTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 140-147 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Amr El Meliegy Ahmad Motawi Mohamed Ahmed Abd El Salam Systematic review of hormone replacement therapy in the infertile man
description	Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age. Materials and methods: We performed a comprehensive literature review for the years 1978–2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed. Review was consistent with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) criteria. We used Medical Subject Heading terms for the search including ‘testosterone replacement therapy’ or ‘TRT’ and ‘male infertility’. Results: In all, 91 manuscripts were screened and the final number used for the review was 56. All studies included were performed in adults, were written in English and had an abstract available. Conclusions: Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. Keywords: Gonadotrophins, Hypogonadism, Infertility, Systematic review, Testosterone therapy
format	article
author	Amr El Meliegy Ahmad Motawi Mohamed Ahmed Abd El Salam
author_facet	Amr El Meliegy Ahmad Motawi Mohamed Ahmed Abd El Salam
author_sort	Amr El Meliegy
title	Systematic review of hormone replacement therapy in the infertile man
title_short	Systematic review of hormone replacement therapy in the infertile man
title_full	Systematic review of hormone replacement therapy in the infertile man
title_fullStr	Systematic review of hormone replacement therapy in the infertile man
title_full_unstemmed	Systematic review of hormone replacement therapy in the infertile man
title_sort	systematic review of hormone replacement therapy in the infertile man
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/3bfadcb20e014c22b7d7aa39dec2411a
work_keys_str_mv	AT amrelmeliegy systematicreviewofhormonereplacementtherapyintheinfertileman AT ahmadmotawi systematicreviewofhormonereplacementtherapyintheinfertileman AT mohamedahmedabdelsalam systematicreviewofhormonereplacementtherapyintheinfertileman
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Systematic review of hormone replacement therapy in the infertile man

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