Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.

Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.

Transcription factors are proteins that regulate gene expression by binding to cis-regulatory sequences such as promoters and enhancers. In embryonic stem (ES) cells, binding of the transcription factors OCT4, SOX2 and NANOG is essential to maintain the capacity of the cells to differentiate into an...

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Autores principales: Jonathan Göke, Marc Jung, Sarah Behrens, Lukas Chavez, Sean O'Keeffe, Bernd Timmermann, Hans Lehrach, James Adjaye, Martin Vingron
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/3bfc2751d06f42d2836d55c1cf76cd49
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