Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures

Abstract Both humans and pet dogs are more prone to develop allergies in urban than in rural environments, which has been associated with the differing microbial exposures between areas. However, potential similarities in the microbiota, that associate with environmental exposures, in allergic dogs...

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Autores principales:	Jenni Lehtimäki, Hanna Sinkko, Anna Hielm-Björkman, Tiina Laatikainen, Lasse Ruokolainen, Hannes Lohi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3bfe9c8027d042fba30cf6907d1a8523
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spelling	oai:doaj.org-article:3bfe9c8027d042fba30cf6907d1a85232021-12-02T13:58:16ZSimultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures10.1038/s41598-020-79055-x2045-2322https://doaj.org/article/3bfe9c8027d042fba30cf6907d1a85232020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79055-xhttps://doaj.org/toc/2045-2322Abstract Both humans and pet dogs are more prone to develop allergies in urban than in rural environments, which has been associated with the differing microbial exposures between areas. However, potential similarities in the microbiota, that associate with environmental exposures, in allergic dogs and owners has not been investigated. We evaluated skin and gut microbiota, living environment, and lifestyle in 168 dog-owner pairs. Due to partly different manifestations of allergies between species, we focused on aeroallergen sensitized humans and dogs with owner-reported allergic symptoms. Our results agree with previous studies: dog-owner pairs suffered simultaneously from these allergic traits, higher risk associated with an urban environment, and the skin, but not gut, microbiota was partly shared by dog-owner pairs. We further discovered that urban environment homogenized both dog and human skin microbiota. Notably, certain bacterial taxa, which were associated with living environment and lifestyle, were also related with allergic traits, but these taxa differed between dogs and humans. Thus, we conclude that dogs and humans can be predisposed to allergy in response to same risk factors. However, as shared predisposing or protective bacterial taxa were not discovered, other factors than environmental microbial exposures can mediate the effect or furry dog and furless human skin select different taxa.Jenni LehtimäkiHanna SinkkoAnna Hielm-BjörkmanTiina LaatikainenLasse RuokolainenHannes LohiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jenni Lehtimäki Hanna Sinkko Anna Hielm-Björkman Tiina Laatikainen Lasse Ruokolainen Hannes Lohi Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
description	Abstract Both humans and pet dogs are more prone to develop allergies in urban than in rural environments, which has been associated with the differing microbial exposures between areas. However, potential similarities in the microbiota, that associate with environmental exposures, in allergic dogs and owners has not been investigated. We evaluated skin and gut microbiota, living environment, and lifestyle in 168 dog-owner pairs. Due to partly different manifestations of allergies between species, we focused on aeroallergen sensitized humans and dogs with owner-reported allergic symptoms. Our results agree with previous studies: dog-owner pairs suffered simultaneously from these allergic traits, higher risk associated with an urban environment, and the skin, but not gut, microbiota was partly shared by dog-owner pairs. We further discovered that urban environment homogenized both dog and human skin microbiota. Notably, certain bacterial taxa, which were associated with living environment and lifestyle, were also related with allergic traits, but these taxa differed between dogs and humans. Thus, we conclude that dogs and humans can be predisposed to allergy in response to same risk factors. However, as shared predisposing or protective bacterial taxa were not discovered, other factors than environmental microbial exposures can mediate the effect or furry dog and furless human skin select different taxa.
format	article
author	Jenni Lehtimäki Hanna Sinkko Anna Hielm-Björkman Tiina Laatikainen Lasse Ruokolainen Hannes Lohi
author_facet	Jenni Lehtimäki Hanna Sinkko Anna Hielm-Björkman Tiina Laatikainen Lasse Ruokolainen Hannes Lohi
author_sort	Jenni Lehtimäki
title	Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
title_short	Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
title_full	Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
title_fullStr	Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
title_full_unstemmed	Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
title_sort	simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3bfe9c8027d042fba30cf6907d1a8523
work_keys_str_mv	AT jennilehtimaki simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures AT hannasinkko simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures AT annahielmbjorkman simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures AT tiinalaatikainen simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures AT lasseruokolainen simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures AT hanneslohi simultaneousallergictraitsindogsandtheirownersareassociatedwithlivingenvironmentlifestyleandmicrobialexposures
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Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures

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