Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL:AZUL complex, which forms an intermolecular 4-...

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Detalles Bibliográficos
Autores principales: Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Thorkell Andresson, Kylie J. Walters
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3bff9a9995c849639e9e6e9b19f0338c
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Sumario:Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL:AZUL complex, which forms an intermolecular 4-helix bundle.

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