Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL:AZUL complex, which forms an intermolecular 4-...

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Autores principales:	Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Thorkell Andresson, Kylie J. Walters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bff9a9995c849639e9e6e9b19f0338c
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spelling	oai:doaj.org-article:3bff9a9995c849639e9e6e9b19f0338c2021-12-02T14:42:12ZStructure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn1010.1038/s41467-020-15073-72041-1723https://doaj.org/article/3bff9a9995c849639e9e6e9b19f0338c2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15073-7https://doaj.org/toc/2041-1723Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL:AZUL complex, which forms an intermolecular 4-helix bundle.Gwen R. BuelXiang ChenRaj ChariMaura J. O’NeillDanielle L. EbelleConor JenkinsVinidhra SridharanSergey G. TarasovNadya I. TarasovaThorkell AndressonKylie J. WaltersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gwen R. Buel Xiang Chen Raj Chari Maura J. O’Neill Danielle L. Ebelle Conor Jenkins Vinidhra Sridharan Sergey G. Tarasov Nadya I. Tarasova Thorkell Andresson Kylie J. Walters Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
description	Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL:AZUL complex, which forms an intermolecular 4-helix bundle.
format	article
author	Gwen R. Buel Xiang Chen Raj Chari Maura J. O’Neill Danielle L. Ebelle Conor Jenkins Vinidhra Sridharan Sergey G. Tarasov Nadya I. Tarasova Thorkell Andresson Kylie J. Walters
author_facet	Gwen R. Buel Xiang Chen Raj Chari Maura J. O’Neill Danielle L. Ebelle Conor Jenkins Vinidhra Sridharan Sergey G. Tarasov Nadya I. Tarasova Thorkell Andresson Kylie J. Walters
author_sort	Gwen R. Buel
title	Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
title_short	Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
title_full	Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
title_fullStr	Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
title_full_unstemmed	Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
title_sort	structure of e3 ligase e6ap with a proteasome-binding site provided by substrate receptor hrpn10
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3bff9a9995c849639e9e6e9b19f0338c
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Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

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