Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and image the brain accumulation of the PHB.eB capsid b...

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Autores principales:	Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
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spelling	oai:doaj.org-article:3bffb0cc262e4293b560a67f7e3c6fd92021-12-02T17:32:25ZPositron emission tomography imaging of novel AAV capsids maps rapid brain accumulation10.1038/s41467-020-15818-42041-1723https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd92020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15818-4https://doaj.org/toc/2041-1723Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and image the brain accumulation of the PHB.eB capsid by PET.Jai Woong SeoElizabeth S. InghamLisa MahakianSpencer TumbaleBo WuSadaf AghevlianShahin ShamsMo BaikoghliPoorva JainXiaozhe DingNick GoedenTatyana DobrevaNicholas C. FlytzanisMichael ChavezKratika SinghalRyan LeibMichelle L. JamesDavid J. SegalR. Holland ChengEduardo A. SilvaViviana GradinaruKatherine W. FerraraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jai Woong Seo Elizabeth S. Ingham Lisa Mahakian Spencer Tumbale Bo Wu Sadaf Aghevlian Shahin Shams Mo Baikoghli Poorva Jain Xiaozhe Ding Nick Goeden Tatyana Dobreva Nicholas C. Flytzanis Michael Chavez Kratika Singhal Ryan Leib Michelle L. James David J. Segal R. Holland Cheng Eduardo A. Silva Viviana Gradinaru Katherine W. Ferrara Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
description	Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and image the brain accumulation of the PHB.eB capsid by PET.
format	article
author	Jai Woong Seo Elizabeth S. Ingham Lisa Mahakian Spencer Tumbale Bo Wu Sadaf Aghevlian Shahin Shams Mo Baikoghli Poorva Jain Xiaozhe Ding Nick Goeden Tatyana Dobreva Nicholas C. Flytzanis Michael Chavez Kratika Singhal Ryan Leib Michelle L. James David J. Segal R. Holland Cheng Eduardo A. Silva Viviana Gradinaru Katherine W. Ferrara
author_facet	Jai Woong Seo Elizabeth S. Ingham Lisa Mahakian Spencer Tumbale Bo Wu Sadaf Aghevlian Shahin Shams Mo Baikoghli Poorva Jain Xiaozhe Ding Nick Goeden Tatyana Dobreva Nicholas C. Flytzanis Michael Chavez Kratika Singhal Ryan Leib Michelle L. James David J. Segal R. Holland Cheng Eduardo A. Silva Viviana Gradinaru Katherine W. Ferrara
author_sort	Jai Woong Seo
title	Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
title_short	Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
title_full	Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
title_fullStr	Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
title_full_unstemmed	Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
title_sort	positron emission tomography imaging of novel aav capsids maps rapid brain accumulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
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Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

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