CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES

Abstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, ea...

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Autores principales:	K. G. Shapovalov, V. A. Sizonenko, Yu. A. Vitkovsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	angiogenesis local frostbites growth factors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3c0587a640ee460798dbf00a636a89f8
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spelling	oai:doaj.org-article:3c0587a640ee460798dbf00a636a89f82021-11-18T08:03:39ZCONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES1563-06252313-741X10.15789/1563-0625-2008-4-5-483-485https://doaj.org/article/3c0587a640ee460798dbf00a636a89f82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/228https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, early reactive period; group 2, late reactive period; group 3, granulation and epithelization of lesions). Quantitative determination of TGFα, TGFβ1 and VEGF in blood was performed by ELISA techniques. Blood samples were taken at early, late reactive periods and at period of epithelization of local frostbites. It was revealed that the contents of TGFα, TGFβ1 and VEGF were increased in patients’ blood at later terms after local frostbites. VEGF contents in blood of the frostbite patients increased to higher degrees than the values of TGFα and TGFβ1. An imbalance between TGFα, TGFβ1 and VEGF contents in frostbites was observed in cases of lagging repair and unfavorable clinical course. (Med. Immunol., vol. 10, N 4-5, pp 483-485).K. G. ShapovalovV. A. SizonenkoYu. A. VitkovskySPb RAACIarticleangiogenesislocal frostbitesgrowth factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 483-485 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	angiogenesis local frostbites growth factors Immunologic diseases. Allergy RC581-607
spellingShingle	angiogenesis local frostbites growth factors Immunologic diseases. Allergy RC581-607 K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
description	Abstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, early reactive period; group 2, late reactive period; group 3, granulation and epithelization of lesions). Quantitative determination of TGFα, TGFβ1 and VEGF in blood was performed by ELISA techniques. Blood samples were taken at early, late reactive periods and at period of epithelization of local frostbites. It was revealed that the contents of TGFα, TGFβ1 and VEGF were increased in patients’ blood at later terms after local frostbites. VEGF contents in blood of the frostbite patients increased to higher degrees than the values of TGFα and TGFβ1. An imbalance between TGFα, TGFβ1 and VEGF contents in frostbites was observed in cases of lagging repair and unfavorable clinical course. (Med. Immunol., vol. 10, N 4-5, pp 483-485).
format	article
author	K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky
author_facet	K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky
author_sort	K. G. Shapovalov
title	CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
title_short	CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
title_full	CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
title_fullStr	CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
title_full_unstemmed	CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
title_sort	contents of angiogenic growth factors in the patients with local frostbites
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/3c0587a640ee460798dbf00a636a89f8
work_keys_str_mv	AT kgshapovalov contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites AT vasizonenko contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites AT yuavitkovsky contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites
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CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES

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