Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea

Abstract The objective of our study was to evaluate the effects of upper-airway surgery on improvement of endothelial function-related markers in patients with obstructive sleep apnea (OSA). Subjects with moderate to severe OSA who underwent upper-airway surgery, with a follow-up duration of at leas...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fan Wang, Yuenan Liu, Huajun Xu, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan, Shankai Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c05a7c843a24ebabedff7c9eae97958
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3c05a7c843a24ebabedff7c9eae97958
record_format	dspace
spelling	oai:doaj.org-article:3c05a7c843a24ebabedff7c9eae979582021-12-02T13:35:11ZAssociation between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea10.1038/s41598-019-56601-w2045-2322https://doaj.org/article/3c05a7c843a24ebabedff7c9eae979582019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56601-whttps://doaj.org/toc/2045-2322Abstract The objective of our study was to evaluate the effects of upper-airway surgery on improvement of endothelial function-related markers in patients with obstructive sleep apnea (OSA). Subjects with moderate to severe OSA who underwent upper-airway surgery, with a follow-up duration of at least 6 months, were included. Pre- and postoperative polysomnographic variables and endothelial function-related markers were compared. Subgroup and correlation analyses were conducted to find possible indicators for better endothelial function-related markers after upper-airway surgery. In total, 44 patients with OSA were included. The mean follow-up duration was 1.72 ± 0.92 years. Serum VEGFA [−20.29 (CI: −35.27, −5.31), p < 0.05], Ang2 [−0.06 (CI: −0.16, 0.03), p < 0.05], E-selectin [−7.21 (CI: −11.01, −3.41), p < 0.001], VWF [−58.83 (CI: −103.93, −13.73), p < 0.05], VWFCP [−33.52 (CI: −66.34, −0.70), p < 0.05], and TM [−0.06 (CI: −0.09, −0.03), p < 0.05] were significantly lower after upper-airway surgery. However, other risk markers of endothelial function, such as Ang1, ICAM1, VEGFR1, and VCAM, did not change significantly. Correlations between improved endothelial function-related markers and ameliorated oxyhemoglobin saturation and glucolipid metabolism were established. Upper-airway surgery might be associated with an improvement in endothelial function in patients with OSA. These changes may be associated with improved oxygen saturation after upper-airway surgery.Fan WangYuenan LiuHuajun XuYingjun QianJianyin ZouHongliang YiJian GuanShankai YinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fan Wang Yuenan Liu Huajun Xu Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan Shankai Yin Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
description	Abstract The objective of our study was to evaluate the effects of upper-airway surgery on improvement of endothelial function-related markers in patients with obstructive sleep apnea (OSA). Subjects with moderate to severe OSA who underwent upper-airway surgery, with a follow-up duration of at least 6 months, were included. Pre- and postoperative polysomnographic variables and endothelial function-related markers were compared. Subgroup and correlation analyses were conducted to find possible indicators for better endothelial function-related markers after upper-airway surgery. In total, 44 patients with OSA were included. The mean follow-up duration was 1.72 ± 0.92 years. Serum VEGFA [−20.29 (CI: −35.27, −5.31), p < 0.05], Ang2 [−0.06 (CI: −0.16, 0.03), p < 0.05], E-selectin [−7.21 (CI: −11.01, −3.41), p < 0.001], VWF [−58.83 (CI: −103.93, −13.73), p < 0.05], VWFCP [−33.52 (CI: −66.34, −0.70), p < 0.05], and TM [−0.06 (CI: −0.09, −0.03), p < 0.05] were significantly lower after upper-airway surgery. However, other risk markers of endothelial function, such as Ang1, ICAM1, VEGFR1, and VCAM, did not change significantly. Correlations between improved endothelial function-related markers and ameliorated oxyhemoglobin saturation and glucolipid metabolism were established. Upper-airway surgery might be associated with an improvement in endothelial function in patients with OSA. These changes may be associated with improved oxygen saturation after upper-airway surgery.
format	article
author	Fan Wang Yuenan Liu Huajun Xu Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan Shankai Yin
author_facet	Fan Wang Yuenan Liu Huajun Xu Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan Shankai Yin
author_sort	Fan Wang
title	Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
title_short	Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
title_full	Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
title_fullStr	Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
title_full_unstemmed	Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea
title_sort	association between upper-airway surgery and ameliorative risk markers of endothelial function in obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3c05a7c843a24ebabedff7c9eae97958
work_keys_str_mv	AT fanwang associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT yuenanliu associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT huajunxu associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT yingjunqian associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT jianyinzou associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT hongliangyi associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT jianguan associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea AT shankaiyin associationbetweenupperairwaysurgeryandameliorativeriskmarkersofendothelialfunctioninobstructivesleepapnea
_version_	1718392668077162496

Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea

Ejemplares similares