Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance

Observations on confluent epithelial tissues show the emergence of dynamic contraction patterns that are suspected to be governed mechanically. Here, the authors propose a model for epithelial sheets and show that cells’ Extension-Induced-Contraction response explains experimentally-observed contrac...

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Autores principales:	Shahaf Armon, Matthew S. Bull, Avraham Moriel, Hillel Aharoni, Manu Prakash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Astrophysics QB460-466 Physics QC1-999
Acceso en línea:	https://doaj.org/article/3c06db2386814e1aa4d11f6b3d43c9e6
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spelling	oai:doaj.org-article:3c06db2386814e1aa4d11f6b3d43c9e62021-12-02T18:48:24ZModeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance10.1038/s42005-021-00712-22399-3650https://doaj.org/article/3c06db2386814e1aa4d11f6b3d43c9e62021-09-01T00:00:00Zhttps://doi.org/10.1038/s42005-021-00712-2https://doaj.org/toc/2399-3650Observations on confluent epithelial tissues show the emergence of dynamic contraction patterns that are suspected to be governed mechanically. Here, the authors propose a model for epithelial sheets and show that cells’ Extension-Induced-Contraction response explains experimentally-observed contraction pulses, that along with a cell softening response enhances epithelial resistance to rupture.Shahaf ArmonMatthew S. BullAvraham MorielHillel AharoniManu PrakashNature PortfolioarticleAstrophysicsQB460-466PhysicsQC1-999ENCommunications Physics, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astrophysics QB460-466 Physics QC1-999
spellingShingle	Astrophysics QB460-466 Physics QC1-999 Shahaf Armon Matthew S. Bull Avraham Moriel Hillel Aharoni Manu Prakash Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
description	Observations on confluent epithelial tissues show the emergence of dynamic contraction patterns that are suspected to be governed mechanically. Here, the authors propose a model for epithelial sheets and show that cells’ Extension-Induced-Contraction response explains experimentally-observed contraction pulses, that along with a cell softening response enhances epithelial resistance to rupture.
format	article
author	Shahaf Armon Matthew S. Bull Avraham Moriel Hillel Aharoni Manu Prakash
author_facet	Shahaf Armon Matthew S. Bull Avraham Moriel Hillel Aharoni Manu Prakash
author_sort	Shahaf Armon
title	Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
title_short	Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
title_full	Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
title_fullStr	Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
title_full_unstemmed	Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
title_sort	modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c06db2386814e1aa4d11f6b3d43c9e6
work_keys_str_mv	AT shahafarmon modelingepithelialtissuesasactiveelasticsheetsreproducecontractionpulsesandpredictripresistance AT matthewsbull modelingepithelialtissuesasactiveelasticsheetsreproducecontractionpulsesandpredictripresistance AT avrahammoriel modelingepithelialtissuesasactiveelasticsheetsreproducecontractionpulsesandpredictripresistance AT hillelaharoni modelingepithelialtissuesasactiveelasticsheetsreproducecontractionpulsesandpredictripresistance AT manuprakash modelingepithelialtissuesasactiveelasticsheetsreproducecontractionpulsesandpredictripresistance
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Modeling epithelial tissues as active-elastic sheets reproduce contraction pulses and predict rip resistance

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