Cellular Technologies in Traumatology: from Cells to Tissue Engineering

Severe injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The arti...

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Autores principales:	N. N. Dremina, I. S. Trukhan, I. A. Shurygina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	сell technologies mesenchymal stem cells reparation traumatology bone cartilage Science Q
Acceso en línea:	https://doaj.org/article/3c08a09a095a490ca0a3f9a7920aad23
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spelling	oai:doaj.org-article:3c08a09a095a490ca0a3f9a7920aad232021-11-23T06:14:45ZCellular Technologies in Traumatology: from Cells to Tissue Engineering2541-94202587-959610.29413/ABS.2020-5.6.8https://doaj.org/article/3c08a09a095a490ca0a3f9a7920aad232021-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2497https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Severe injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The article deals with the prospects for developing the new areas in the traumatological pathology treatment based on the cell technologies application. Both medical and ethical aspects of the cell technology usage and the utilizing various sources of cell material for transplantation are discussed in detail. Special attention is devoted to application of the mesenchymal stem cells as the most suitable material for bone and cartilage repair. These cells possess the properties of multipotent stem cells that can adhere to plastic surfaces, differentiate into various cells, including chondroblasts, osteoblasts, and migrate to the damaged area. It is shown that the number and biological characteristics of the isolated cells depend on the tissue, the cell isolation method, and the culture medium. During the cultivation of mesenchymal stem cells, the true marker of which is Stro-1, it is necessary to monitor the duration and number of passages, because these values are inversely correlated with the differentiating potential of cells, and spontaneous transformation according to oncogenic pathway may occur. Thus, mesenchymal stem cells represent a current material for the reconstruction of hard tissues. Despite ethical and technological problems, cell technologies are a promising approach in regenerative medicine.N. N. DreminaI. S. TrukhanI. A. ShuryginaScientific Сentre for Family Health and Human Reproduction Problemsarticleсell technologiesmesenchymal stem cellsreparationtraumatologybonecartilageScienceQRUActa Biomedica Scientifica, Vol 5, Iss 6, Pp 66-76 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	сell technologies mesenchymal stem cells reparation traumatology bone cartilage Science Q
spellingShingle	сell technologies mesenchymal stem cells reparation traumatology bone cartilage Science Q N. N. Dremina I. S. Trukhan I. A. Shurygina Cellular Technologies in Traumatology: from Cells to Tissue Engineering
description	Severe injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The article deals with the prospects for developing the new areas in the traumatological pathology treatment based on the cell technologies application. Both medical and ethical aspects of the cell technology usage and the utilizing various sources of cell material for transplantation are discussed in detail. Special attention is devoted to application of the mesenchymal stem cells as the most suitable material for bone and cartilage repair. These cells possess the properties of multipotent stem cells that can adhere to plastic surfaces, differentiate into various cells, including chondroblasts, osteoblasts, and migrate to the damaged area. It is shown that the number and biological characteristics of the isolated cells depend on the tissue, the cell isolation method, and the culture medium. During the cultivation of mesenchymal stem cells, the true marker of which is Stro-1, it is necessary to monitor the duration and number of passages, because these values are inversely correlated with the differentiating potential of cells, and spontaneous transformation according to oncogenic pathway may occur. Thus, mesenchymal stem cells represent a current material for the reconstruction of hard tissues. Despite ethical and technological problems, cell technologies are a promising approach in regenerative medicine.
format	article
author	N. N. Dremina I. S. Trukhan I. A. Shurygina
author_facet	N. N. Dremina I. S. Trukhan I. A. Shurygina
author_sort	N. N. Dremina
title	Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_short	Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_full	Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_fullStr	Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_full_unstemmed	Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_sort	cellular technologies in traumatology: from cells to tissue engineering
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/3c08a09a095a490ca0a3f9a7920aad23
work_keys_str_mv	AT nndremina cellulartechnologiesintraumatologyfromcellstotissueengineering AT istrukhan cellulartechnologiesintraumatologyfromcellstotissueengineering AT iashurygina cellulartechnologiesintraumatologyfromcellstotissueengineering
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Cellular Technologies in Traumatology: from Cells to Tissue Engineering

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