Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump

Abstract The specific hemocompatibility properties of mechanical-circulatory-support (MCS)-pump technologies have not previously been described in a comparable manner. We thus investigated the hemocompatibility-indicating marker of a new magnetically-levitated (MagLev) centrifugal pump (MT-Mag) in a...

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Autores principales:	David Schibilsky, Setsuo Takatani, Barbara Schibilsky, Tobias Graf, Diana Michels da Silva, Hans Peter Wendel, Meltem Avci-Adali, Christian Schlensak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c09ace527474b75b80c2b7b34381cb0
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spelling	oai:doaj.org-article:3c09ace527474b75b80c2b7b34381cb02021-12-02T11:57:58ZHemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump10.1038/s41598-020-78709-02045-2322https://doaj.org/article/3c09ace527474b75b80c2b7b34381cb02020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78709-0https://doaj.org/toc/2045-2322Abstract The specific hemocompatibility properties of mechanical-circulatory-support (MCS)-pump technologies have not previously been described in a comparable manner. We thus investigated the hemocompatibility-indicating marker of a new magnetically-levitated (MagLev) centrifugal pump (MT-Mag) in a human, whole-blood mock-loop for 360 min using the MCS devices as a driving component. We compared those results with the CentriMag adult (C-Mag) device under the same conditions according to ISO10993-4. Blood samples were analyzed via enzyme-linked-immunosorbent-assay (ELISA) for markers of coagulation, complement system, and the inflammatory response. The time-dependent activation of the coagulation system was measured by detecting thrombin-anti-thrombin complexes (TAT). The activation of the complement system was determined by increased SC5b-9 levels in both groups. A significant activation of neutrophils (PMN-elastase) was detected within the C-Mag group, but not in the MT-Mag group. However, the amount of PMN-elastase at 360 min did not differ significantly between groups. The activation of the complement and coagulation system was found to be significantly time-dependent in both devices. However, coagulation activation as determined by the TAT level was lower in the MT-Mag group than in the C-Mag group. This slight disparity could have been achieved by the optimized secondary flow paths and surface coating, which reduces the interaction of the surface with blood.David SchibilskySetsuo TakataniBarbara SchibilskyTobias GrafDiana Michels da SilvaHans Peter WendelMeltem Avci-AdaliChristian SchlensakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Schibilsky Setsuo Takatani Barbara Schibilsky Tobias Graf Diana Michels da Silva Hans Peter Wendel Meltem Avci-Adali Christian Schlensak Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
description	Abstract The specific hemocompatibility properties of mechanical-circulatory-support (MCS)-pump technologies have not previously been described in a comparable manner. We thus investigated the hemocompatibility-indicating marker of a new magnetically-levitated (MagLev) centrifugal pump (MT-Mag) in a human, whole-blood mock-loop for 360 min using the MCS devices as a driving component. We compared those results with the CentriMag adult (C-Mag) device under the same conditions according to ISO10993-4. Blood samples were analyzed via enzyme-linked-immunosorbent-assay (ELISA) for markers of coagulation, complement system, and the inflammatory response. The time-dependent activation of the coagulation system was measured by detecting thrombin-anti-thrombin complexes (TAT). The activation of the complement system was determined by increased SC5b-9 levels in both groups. A significant activation of neutrophils (PMN-elastase) was detected within the C-Mag group, but not in the MT-Mag group. However, the amount of PMN-elastase at 360 min did not differ significantly between groups. The activation of the complement and coagulation system was found to be significantly time-dependent in both devices. However, coagulation activation as determined by the TAT level was lower in the MT-Mag group than in the C-Mag group. This slight disparity could have been achieved by the optimized secondary flow paths and surface coating, which reduces the interaction of the surface with blood.
format	article
author	David Schibilsky Setsuo Takatani Barbara Schibilsky Tobias Graf Diana Michels da Silva Hans Peter Wendel Meltem Avci-Adali Christian Schlensak
author_facet	David Schibilsky Setsuo Takatani Barbara Schibilsky Tobias Graf Diana Michels da Silva Hans Peter Wendel Meltem Avci-Adali Christian Schlensak
author_sort	David Schibilsky
title	Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
title_short	Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
title_full	Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
title_fullStr	Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
title_full_unstemmed	Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump
title_sort	hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the centrimag adult pump
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c09ace527474b75b80c2b7b34381cb0
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Hemocompatibility of new magnetically-levitated centrifugal pump technology compared to the CentriMag adult pump

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