Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus

Abstract The effects of testosterone and flutamide on reproduction in Brachionus calyciflorus were studied. Asexual reproduction in B. calyciflorus was not affected by testosterone at different concentrations of flutamide. Flutamide in combination with 0, 25, 50, or 75 µg L−1 testosterone had a sign...

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Autores principales:	Jian Tian, Lulu Liu, Yajie Han, Yuanhao Yang, Sichen Jin, Jiaxin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c0a65cd6c414f12925aae617e4166ef
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spelling	oai:doaj.org-article:3c0a65cd6c414f12925aae617e4166ef2021-12-02T16:07:56ZEffects of testosterone and flutamide on reproduction in Brachionus calyciflorus10.1038/s41598-017-05517-42045-2322https://doaj.org/article/3c0a65cd6c414f12925aae617e4166ef2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05517-4https://doaj.org/toc/2045-2322Abstract The effects of testosterone and flutamide on reproduction in Brachionus calyciflorus were studied. Asexual reproduction in B. calyciflorus was not affected by testosterone at different concentrations of flutamide. Flutamide in combination with 0, 25, 50, or 75 µg L−1 testosterone had a significant effect on mixis rate. The combination of 5 µg L−1 flutamide with 25 µg L−1 or 50 µg L−1 testosterone resulted in a mixis rate that was 2.2× lower than that with flutamide alone. Fertilization rate was significantly decreased by 7.5 µg L−1 flutamide in combination with 25, 50, or 75 µg L−1 testosterone. The number of resting eggs produced per mictic female was significantly lower at all concentrations of testosterone. A low concentration of flutamide in combination with testosterone resulted in antagonism, increasing the number of resting eggs produced. However, when testosterone was combined with a higher concentration of flutamide, resting egg production declined. Therefore, long-term exposure to either testosterone, flutamide, or a combination of these two compounds may significantly reduce resting egg production in rotifers. This implies that resting egg production is affected differently by hormone pathways.Jian TianLulu LiuYajie HanYuanhao YangSichen JinJiaxin YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Tian Lulu Liu Yajie Han Yuanhao Yang Sichen Jin Jiaxin Yang Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
description	Abstract The effects of testosterone and flutamide on reproduction in Brachionus calyciflorus were studied. Asexual reproduction in B. calyciflorus was not affected by testosterone at different concentrations of flutamide. Flutamide in combination with 0, 25, 50, or 75 µg L−1 testosterone had a significant effect on mixis rate. The combination of 5 µg L−1 flutamide with 25 µg L−1 or 50 µg L−1 testosterone resulted in a mixis rate that was 2.2× lower than that with flutamide alone. Fertilization rate was significantly decreased by 7.5 µg L−1 flutamide in combination with 25, 50, or 75 µg L−1 testosterone. The number of resting eggs produced per mictic female was significantly lower at all concentrations of testosterone. A low concentration of flutamide in combination with testosterone resulted in antagonism, increasing the number of resting eggs produced. However, when testosterone was combined with a higher concentration of flutamide, resting egg production declined. Therefore, long-term exposure to either testosterone, flutamide, or a combination of these two compounds may significantly reduce resting egg production in rotifers. This implies that resting egg production is affected differently by hormone pathways.
format	article
author	Jian Tian Lulu Liu Yajie Han Yuanhao Yang Sichen Jin Jiaxin Yang
author_facet	Jian Tian Lulu Liu Yajie Han Yuanhao Yang Sichen Jin Jiaxin Yang
author_sort	Jian Tian
title	Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
title_short	Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
title_full	Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
title_fullStr	Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
title_full_unstemmed	Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus
title_sort	effects of testosterone and flutamide on reproduction in brachionus calyciflorus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3c0a65cd6c414f12925aae617e4166ef
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Effects of testosterone and flutamide on reproduction in Brachionus calyciflorus

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