Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these...

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Autores principales:	Heike Stein, Joao Barbosa, Mireia Rosa-Justicia, Laia Prades, Alba Morató, Adrià Galan-Gadea, Helena Ariño, Eugenia Martinez-Hernandez, Josefina Castro-Fornieles, Josep Dalmau, Albert Compte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c0b233c5a824a62896a182e689b957d
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spelling	oai:doaj.org-article:3c0b233c5a824a62896a182e689b957d2021-12-02T18:53:20ZReduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia10.1038/s41467-020-18033-32041-1723https://doaj.org/article/3c0b233c5a824a62896a182e689b957d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18033-3https://doaj.org/toc/2041-1723Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.Heike SteinJoao BarbosaMireia Rosa-JusticiaLaia PradesAlba MoratóAdrià Galan-GadeaHelena AriñoEugenia Martinez-HernandezJosefina Castro-FornielesJosep DalmauAlbert CompteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heike Stein Joao Barbosa Mireia Rosa-Justicia Laia Prades Alba Morató Adrià Galan-Gadea Helena Ariño Eugenia Martinez-Hernandez Josefina Castro-Fornieles Josep Dalmau Albert Compte Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
description	Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.
format	article
author	Heike Stein Joao Barbosa Mireia Rosa-Justicia Laia Prades Alba Morató Adrià Galan-Gadea Helena Ariño Eugenia Martinez-Hernandez Josefina Castro-Fornieles Josep Dalmau Albert Compte
author_facet	Heike Stein Joao Barbosa Mireia Rosa-Justicia Laia Prades Alba Morató Adrià Galan-Gadea Helena Ariño Eugenia Martinez-Hernandez Josefina Castro-Fornieles Josep Dalmau Albert Compte
author_sort	Heike Stein
title	Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
title_short	Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
title_full	Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
title_fullStr	Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
title_full_unstemmed	Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
title_sort	reduced serial dependence suggests deficits in synaptic potentiation in anti-nmdar encephalitis and schizophrenia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c0b233c5a824a62896a182e689b957d
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Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

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