The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.

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Detalles Bibliográficos
Autores principales: Navdeep Malik, Hualong Yan, Nellie Moshkovich, Murali Palangat, Howard Yang, Vanesa Sanchez, Zhuo Cai, Tyler J. Peat, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Beverly A. Mock, Stuart H. Yuspa, Daniel Larson, Lalage M. Wakefield, Jing Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb
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Descripción
Sumario:CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.

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