The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3c11e12f7be441d2bf872bf286db67bb |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3c11e12f7be441d2bf872bf286db67bb2021-12-02T16:57:23ZThe transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription10.1038/s41467-019-10102-62041-1723https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10102-6https://doaj.org/toc/2041-1723CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.Navdeep MalikHualong YanNellie MoshkovichMurali PalangatHoward YangVanesa SanchezZhuo CaiTyler J. PeatShunlin JiangChengyu LiuMaxwell LeeBeverly A. MockStuart H. YuspaDaniel LarsonLalage M. WakefieldJing HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Navdeep Malik Hualong Yan Nellie Moshkovich Murali Palangat Howard Yang Vanesa Sanchez Zhuo Cai Tyler J. Peat Shunlin Jiang Chengyu Liu Maxwell Lee Beverly A. Mock Stuart H. Yuspa Daniel Larson Lalage M. Wakefield Jing Huang The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| description |
CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B. |
| format |
article |
| author |
Navdeep Malik Hualong Yan Nellie Moshkovich Murali Palangat Howard Yang Vanesa Sanchez Zhuo Cai Tyler J. Peat Shunlin Jiang Chengyu Liu Maxwell Lee Beverly A. Mock Stuart H. Yuspa Daniel Larson Lalage M. Wakefield Jing Huang |
| author_facet |
Navdeep Malik Hualong Yan Nellie Moshkovich Murali Palangat Howard Yang Vanesa Sanchez Zhuo Cai Tyler J. Peat Shunlin Jiang Chengyu Liu Maxwell Lee Beverly A. Mock Stuart H. Yuspa Daniel Larson Lalage M. Wakefield Jing Huang |
| author_sort |
Navdeep Malik |
| title |
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| title_short |
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| title_full |
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| title_fullStr |
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| title_full_unstemmed |
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription |
| title_sort |
transcription factor cbfb suppresses breast cancer through orchestrating translation and transcription |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb |
| work_keys_str_mv |
AT navdeepmalik thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT hualongyan thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT nelliemoshkovich thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT muralipalangat thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT howardyang thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT vanesasanchez thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT zhuocai thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT tylerjpeat thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT shunlinjiang thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT chengyuliu thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT maxwelllee thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT beverlyamock thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT stuarthyuspa thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT daniellarson thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT lalagemwakefield thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT jinghuang thetranscriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT navdeepmalik transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT hualongyan transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT nelliemoshkovich transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT muralipalangat transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT howardyang transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT vanesasanchez transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT zhuocai transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT tylerjpeat transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT shunlinjiang transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT chengyuliu transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT maxwelllee transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT beverlyamock transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT stuarthyuspa transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT daniellarson transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT lalagemwakefield transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription AT jinghuang transcriptionfactorcbfbsuppressesbreastcancerthroughorchestratingtranslationandtranscription |
| _version_ |
1718382559076810752 |