The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as to h...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
eLife Sciences Publications Ltd
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77 |
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