The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as to h...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Braulio Bonilla, Alexander J Brown, Sarah R Hengel, Kyle S Rapchak, Debra Mitchell, Catherine A Pressimone, Adeola A Fagunloye, Thong T Luong, Reagan A Russell, Rudri K Vyas, Tony M Mertz, Hani S Zaher, Nima Mosammaparast, Ewa P Malc, Piotr A Mieczkowski, Steven A Roberts, Kara A Bernstein
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
Sujets:
Rad51 paralogs
Shu complex
DNA repair
alkyation damage
homologous recombination
Rad51
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77

Documents similaires