Identification of Mutations in the <italic toggle="yes">mrdA</italic> Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of <named-content content-type="genus-species">Escherichia coli</named-content> Clinical Isolates with Mutations in <italic toggle="yes">ftsI</italic> (PBP3) and Which Carry <italic toggle="yes">bla</italic><sub>NDM-1</sub>
ABSTRACT Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics. We identified mutations in the mrdA gene encoding the PBP2 protein in two Escherichia coli blaNDM-1 clinical isolates th...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3c130500a04c493ebeeaca6cf0d68b31 |
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