Identification of Mutations in the <italic toggle="yes">mrdA</italic> Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of <named-content content-type="genus-species">Escherichia coli</named-content> Clinical Isolates with Mutations in <italic toggle="yes">ftsI</italic> (PBP3) and Which Carry <italic toggle="yes">bla</italic><sub>NDM-1</sub>

Identification of Mutations in the <italic toggle="yes">mrdA</italic> Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of <named-content content-type="genus-species">Escherichia coli</named-content> Clinical Isolates with Mutations in <italic toggle="yes">ftsI</italic> (PBP3) and Which Carry <italic toggle="yes">bla</italic><sub>NDM-1</sub>

ABSTRACT Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics. We identified mutations in the mrdA gene encoding the PBP2 protein in two Escherichia coli blaNDM-1 clinical isolates th...

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Autores principales: Srijan Ranjitkar, Folkert Reck, Xiaobo Ke, Qingming Zhu, Glenn McEnroe, Sara L. Lopez, Charles R. Dean
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
NDM-1
carbapenems
diazabicyclooctane
penicillin-binding proteins
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/3c130500a04c493ebeeaca6cf0d68b31
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