Microfluidic transfection of mRNA into human primary lymphocytes and hematopoietic stem and progenitor cells using ultra-fast physical deformations

Microfluidic transfection of mRNA into human primary lymphocytes and hematopoietic stem and progenitor cells using ultra-fast physical deformations

Abstract Messenger RNA (mRNA) delivery provides gene therapy with the potential to achieve transient therapeutic efficacy without risk of insertional mutagenesis. Amongst other applications, mRNA can be employed as a platform to deliver gene editing molecules, to achieve protein expression as an alt...

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Autores principales: Jocelyn Loo, Ian Sicher, Ailin Goff, Ockchul Kim, Nicole Clary, Alexander Alexeev, Todd Sulchek, Alla Zamarayeva, Sewoon Han, Miguel Calero-Garcia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/3c1817175ef14e56ba195de35e1cb00e
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