Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis

Zhi-Yong Zhang, Ming-Xu Li, Hai Yu, Jun Zhao, Feng-Lin Xiao, Fang Xuan, Yi-Xin Zhao Department of Nephrology, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Ming-Xu LiDepartment of Nephrology, The Sixth Medical Center of PLA General Hos...

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Autores principales:	Zhang ZY, Li MX, Yu H, Zhao J, Xiao FL, Xuan F, Zhao YX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	maintenance hemodialysis hemodialysis hemodiafiltration hemoperfusion end-stage renal failure Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3c1b76eb388a44dea7176cff46694d5c
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spelling	oai:doaj.org-article:3c1b76eb388a44dea7176cff46694d5c2021-12-02T14:08:53ZCombination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis1178-203Xhttps://doaj.org/article/3c1b76eb388a44dea7176cff46694d5c2021-01-01T00:00:00Zhttps://www.dovepress.com/combination-of-multiple-hemodialysis-modes-better-treatment-options-fo-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XZhi-Yong Zhang, Ming-Xu Li, Hai Yu, Jun Zhao, Feng-Lin Xiao, Fang Xuan, Yi-Xin Zhao Department of Nephrology, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Ming-Xu LiDepartment of Nephrology, The Sixth Medical Center of PLA General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, People’s Republic of ChinaTel +86-18600310159Email lmx1964bw@sina.comPurpose: Chronic renal failure has become a major public health concern and treatment strategies are urgently needed. We aimed to investigate whether combination of hemodialysis modes was superior to regular hemodialysis for patients under maintenance hemodialysis.Patients and Methods: A total of 144 patients with end-stage renal failure (ESRF) were enrolled in this single-center retrospective study. Patients received regular hemodialysis (HD) were included in HD group (n=52), patients received regular HD plus hemodiafiltration (HDF) in HD/HDF group (n=47), patients received the combination of regular HD, HDF and hemoperfusion (HP) in HD/HDF/HP group (n=45). After 1-month and 24-months treatment, therapeutic effects were assessed in terms of nutritional status, control of complications, dialysis adequacy, mean arterial pressure (MAP), infection rate and living quality.Results: When patients received 1-month treatment, there were no statistically significant differences among three groups. After 24-months treatment, patients in HD/HDF and HD/HDF/HP group presented with better dialysis adequacy, lower MAP and infection rate, higher serum albumin, hemoglobin and calcium levels, lower serum phosphorus and intact parathyroid hormone levels, lower incidence of malnutrition and the Hamilton Depression Scale score, higher the Barthel Index score than HD group (P< 0.05). The levels of calcium, phosphorus and intact parathyroid hormone in HD/HDF/HP group were lower than those in HD/HDF group (P< 0.05).Conclusion: Our finding highly indicated that combination of hemodialysis modes was superior to regular HD for patients with ESRF in nutritional status, control of complications, dialysis adequacy, and living quality.Keywords: maintenance hemodialysis, hemodialysis, hemodiafiltration, hemoperfusion, end-stage renal failureZhang ZYLi MXYu HZhao JXiao FLXuan FZhao YXDove Medical Pressarticlemaintenance hemodialysishemodialysishemodiafiltrationhemoperfusionend-stage renal failureTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 127-133 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	maintenance hemodialysis hemodialysis hemodiafiltration hemoperfusion end-stage renal failure Therapeutics. Pharmacology RM1-950
spellingShingle	maintenance hemodialysis hemodialysis hemodiafiltration hemoperfusion end-stage renal failure Therapeutics. Pharmacology RM1-950 Zhang ZY Li MX Yu H Zhao J Xiao FL Xuan F Zhao YX Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
description	Zhi-Yong Zhang, Ming-Xu Li, Hai Yu, Jun Zhao, Feng-Lin Xiao, Fang Xuan, Yi-Xin Zhao Department of Nephrology, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Ming-Xu LiDepartment of Nephrology, The Sixth Medical Center of PLA General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, People’s Republic of ChinaTel +86-18600310159Email lmx1964bw@sina.comPurpose: Chronic renal failure has become a major public health concern and treatment strategies are urgently needed. We aimed to investigate whether combination of hemodialysis modes was superior to regular hemodialysis for patients under maintenance hemodialysis.Patients and Methods: A total of 144 patients with end-stage renal failure (ESRF) were enrolled in this single-center retrospective study. Patients received regular hemodialysis (HD) were included in HD group (n=52), patients received regular HD plus hemodiafiltration (HDF) in HD/HDF group (n=47), patients received the combination of regular HD, HDF and hemoperfusion (HP) in HD/HDF/HP group (n=45). After 1-month and 24-months treatment, therapeutic effects were assessed in terms of nutritional status, control of complications, dialysis adequacy, mean arterial pressure (MAP), infection rate and living quality.Results: When patients received 1-month treatment, there were no statistically significant differences among three groups. After 24-months treatment, patients in HD/HDF and HD/HDF/HP group presented with better dialysis adequacy, lower MAP and infection rate, higher serum albumin, hemoglobin and calcium levels, lower serum phosphorus and intact parathyroid hormone levels, lower incidence of malnutrition and the Hamilton Depression Scale score, higher the Barthel Index score than HD group (P< 0.05). The levels of calcium, phosphorus and intact parathyroid hormone in HD/HDF/HP group were lower than those in HD/HDF group (P< 0.05).Conclusion: Our finding highly indicated that combination of hemodialysis modes was superior to regular HD for patients with ESRF in nutritional status, control of complications, dialysis adequacy, and living quality.Keywords: maintenance hemodialysis, hemodialysis, hemodiafiltration, hemoperfusion, end-stage renal failure
format	article
author	Zhang ZY Li MX Yu H Zhao J Xiao FL Xuan F Zhao YX
author_facet	Zhang ZY Li MX Yu H Zhao J Xiao FL Xuan F Zhao YX
author_sort	Zhang ZY
title	Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
title_short	Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
title_full	Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
title_fullStr	Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
title_full_unstemmed	Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
title_sort	combination of multiple hemodialysis modes: better treatment options for patients under maintenance hemodialysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3c1b76eb388a44dea7176cff46694d5c
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Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis

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