Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose concomitant inhibition may have therapeutic utility.

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Autores principales:	Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374
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spelling	oai:doaj.org-article:3c1c97f9f96f44b8b385caffd639b3742021-12-02T17:06:02ZCompensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism10.1038/ncomms159652041-1723https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b3742017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15965https://doaj.org/toc/2041-1723Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose concomitant inhibition may have therapeutic utility.Douglas E. BiancurJoao A. PauloBeata MałachowskaMaria Quiles Del ReyCristovão M. SousaXiaoxu WangAlbert S. W. SohnGerald C. ChuSteven P. GygiJ. Wade HarperWojciech FendlerJoseph D. ManciasAlec C. KimmelmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Douglas E. Biancur Joao A. Paulo Beata Małachowska Maria Quiles Del Rey Cristovão M. Sousa Xiaoxu Wang Albert S. W. Sohn Gerald C. Chu Steven P. Gygi J. Wade Harper Wojciech Fendler Joseph D. Mancias Alec C. Kimmelman Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
description	Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose concomitant inhibition may have therapeutic utility.
format	article
author	Douglas E. Biancur Joao A. Paulo Beata Małachowska Maria Quiles Del Rey Cristovão M. Sousa Xiaoxu Wang Albert S. W. Sohn Gerald C. Chu Steven P. Gygi J. Wade Harper Wojciech Fendler Joseph D. Mancias Alec C. Kimmelman
author_facet	Douglas E. Biancur Joao A. Paulo Beata Małachowska Maria Quiles Del Rey Cristovão M. Sousa Xiaoxu Wang Albert S. W. Sohn Gerald C. Chu Steven P. Gygi J. Wade Harper Wojciech Fendler Joseph D. Mancias Alec C. Kimmelman
author_sort	Douglas E. Biancur
title	Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
title_short	Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
title_full	Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
title_fullStr	Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
title_full_unstemmed	Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
title_sort	compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

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