Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.
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Nature Portfolio
2019
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oai:doaj.org-article:3c1d1aa1326641e8904a43901d3324f82021-12-02T16:57:19ZCommunity assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen10.1038/s41467-019-09799-22041-1723https://doaj.org/article/3c1d1aa1326641e8904a43901d3324f82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09799-2https://doaj.org/toc/2041-1723Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.Michael P. MendenDennis WangMike J. MasonBence SzalaiKrishna C. BulusuYuanfang GuanThomas YuJaewoo KangMinji JeonRuss WolfingerTin NguyenMikhail ZaslavskiyAstraZeneca-Sanger Drug Combination DREAM ConsortiumIn Sock JangZara GhazouiMehmet Eren AhsenRobert VogelElias Chaibub NetoThea NormanEric K. Y. TangMathew J. GarnettGiovanni Y. Di VeroliStephen FawellGustavo StolovitzkyJustin GuinneyJonathan R. DryJulio Saez-RodriguezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Michael P. Menden Dennis Wang Mike J. Mason Bence Szalai Krishna C. Bulusu Yuanfang Guan Thomas Yu Jaewoo Kang Minji Jeon Russ Wolfinger Tin Nguyen Mikhail Zaslavskiy AstraZeneca-Sanger Drug Combination DREAM Consortium In Sock Jang Zara Ghazoui Mehmet Eren Ahsen Robert Vogel Elias Chaibub Neto Thea Norman Eric K. Y. Tang Mathew J. Garnett Giovanni Y. Di Veroli Stephen Fawell Gustavo Stolovitzky Justin Guinney Jonathan R. Dry Julio Saez-Rodriguez Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| description |
Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies. |
| format |
article |
| author |
Michael P. Menden Dennis Wang Mike J. Mason Bence Szalai Krishna C. Bulusu Yuanfang Guan Thomas Yu Jaewoo Kang Minji Jeon Russ Wolfinger Tin Nguyen Mikhail Zaslavskiy AstraZeneca-Sanger Drug Combination DREAM Consortium In Sock Jang Zara Ghazoui Mehmet Eren Ahsen Robert Vogel Elias Chaibub Neto Thea Norman Eric K. Y. Tang Mathew J. Garnett Giovanni Y. Di Veroli Stephen Fawell Gustavo Stolovitzky Justin Guinney Jonathan R. Dry Julio Saez-Rodriguez |
| author_facet |
Michael P. Menden Dennis Wang Mike J. Mason Bence Szalai Krishna C. Bulusu Yuanfang Guan Thomas Yu Jaewoo Kang Minji Jeon Russ Wolfinger Tin Nguyen Mikhail Zaslavskiy AstraZeneca-Sanger Drug Combination DREAM Consortium In Sock Jang Zara Ghazoui Mehmet Eren Ahsen Robert Vogel Elias Chaibub Neto Thea Norman Eric K. Y. Tang Mathew J. Garnett Giovanni Y. Di Veroli Stephen Fawell Gustavo Stolovitzky Justin Guinney Jonathan R. Dry Julio Saez-Rodriguez |
| author_sort |
Michael P. Menden |
| title |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| title_short |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| title_full |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| title_fullStr |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| title_full_unstemmed |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| title_sort |
community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3c1d1aa1326641e8904a43901d3324f8 |
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