Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen

Several cancers harbour mutant p53 and express higher levels of p53-derived peptide-MHCs. Here, the authors report affinity matured human antibody, P1C1TM, specific for the p53125-134 peptide in complex with the HLA-A24 class I MHC molecule and show its efficacy and specificity for mutant p53 expres...

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Autores principales:	Lionel Low, Angeline Goh, Joanna Koh, Samantha Lim, Cheng-I Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c1e92462ee14f2ea327ed6a4ce0ed9d
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spelling	oai:doaj.org-article:3c1e92462ee14f2ea327ed6a4ce0ed9d2021-12-02T17:01:51ZTargeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen10.1038/s41467-019-13305-z2041-1723https://doaj.org/article/3c1e92462ee14f2ea327ed6a4ce0ed9d2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13305-zhttps://doaj.org/toc/2041-1723Several cancers harbour mutant p53 and express higher levels of p53-derived peptide-MHCs. Here, the authors report affinity matured human antibody, P1C1TM, specific for the p53125-134 peptide in complex with the HLA-A24 class I MHC molecule and show its efficacy and specificity for mutant p53 expressing tumours.Lionel LowAngeline GohJoanna KohSamantha LimCheng-I WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lionel Low Angeline Goh Joanna Koh Samantha Lim Cheng-I Wang Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
description	Several cancers harbour mutant p53 and express higher levels of p53-derived peptide-MHCs. Here, the authors report affinity matured human antibody, P1C1TM, specific for the p53125-134 peptide in complex with the HLA-A24 class I MHC molecule and show its efficacy and specificity for mutant p53 expressing tumours.
format	article
author	Lionel Low Angeline Goh Joanna Koh Samantha Lim Cheng-I Wang
author_facet	Lionel Low Angeline Goh Joanna Koh Samantha Lim Cheng-I Wang
author_sort	Lionel Low
title	Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
title_short	Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
title_full	Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
title_fullStr	Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
title_full_unstemmed	Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
title_sort	targeting mutant p53-expressing tumours with a t cell receptor-like antibody specific for a wild-type antigen
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3c1e92462ee14f2ea327ed6a4ce0ed9d
work_keys_str_mv	AT lionellow targetingmutantp53expressingtumourswithatcellreceptorlikeantibodyspecificforawildtypeantigen AT angelinegoh targetingmutantp53expressingtumourswithatcellreceptorlikeantibodyspecificforawildtypeantigen AT joannakoh targetingmutantp53expressingtumourswithatcellreceptorlikeantibodyspecificforawildtypeantigen AT samanthalim targetingmutantp53expressingtumourswithatcellreceptorlikeantibodyspecificforawildtypeantigen AT chengiwang targetingmutantp53expressingtumourswithatcellreceptorlikeantibodyspecificforawildtypeantigen
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Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen

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