Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen

Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen

Several cancers harbour mutant p53 and express higher levels of p53-derived peptide-MHCs. Here, the authors report affinity matured human antibody, P1C1TM, specific for the p53125-134 peptide in complex with the HLA-A24 class I MHC molecule and show its efficacy and specificity for mutant p53 expres...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lionel Low, Angeline Goh, Joanna Koh, Samantha Lim, Cheng-I Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3c1e92462ee14f2ea327ed6a4ce0ed9d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares