Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry

The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during this cell cycle phase to promote mitotic entry...

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Autores principales:	Jamin B. Hein, Jakob Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c229f6b05174cce8ad33f439aa30a13
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spelling	oai:doaj.org-article:3c229f6b05174cce8ad33f439aa30a132021-12-02T15:34:53ZInterphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry10.1038/ncomms109752041-1723https://doaj.org/article/3c229f6b05174cce8ad33f439aa30a132016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10975https://doaj.org/toc/2041-1723The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during this cell cycle phase to promote mitotic entry.Jamin B. HeinJakob NilssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jamin B. Hein Jakob Nilsson Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
description	The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during this cell cycle phase to promote mitotic entry.
format	article
author	Jamin B. Hein Jakob Nilsson
author_facet	Jamin B. Hein Jakob Nilsson
author_sort	Jamin B. Hein
title	Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
title_short	Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
title_full	Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
title_fullStr	Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
title_full_unstemmed	Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
title_sort	interphase apc/c–cdc20 inhibition by cyclin a2–cdk2 ensures efficient mitotic entry
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3c229f6b05174cce8ad33f439aa30a13
work_keys_str_mv	AT jaminbhein interphaseapcccdc20inhibitionbycyclina2cdk2ensuresefficientmitoticentry AT jakobnilsson interphaseapcccdc20inhibitionbycyclina2cdk2ensuresefficientmitoticentry
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Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry

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