Correlation between electrical characteristics and biomarkers in breast cancer cells

Abstract Both electrical properties and biomarkers of biological tissues can be used to distinguish between normal and diseased tissues, and the correlations between them are critical for clinical applications of conductivity (σ) and permittivity (ε); however, these correlations remain unknown. This...

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Autores principales:	Yang Wang, Ying Li, Jie Huang, Yan Zhang, Ren Ma, Shunqi Zhang, Tao Yin, Shangmei Liu, Yan Song, Zhipeng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c22fc53d3f34a668d3837e2d390bea9
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spelling	oai:doaj.org-article:3c22fc53d3f34a668d3837e2d390bea92021-12-02T16:08:07ZCorrelation between electrical characteristics and biomarkers in breast cancer cells10.1038/s41598-021-93793-62045-2322https://doaj.org/article/3c22fc53d3f34a668d3837e2d390bea92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93793-6https://doaj.org/toc/2045-2322Abstract Both electrical properties and biomarkers of biological tissues can be used to distinguish between normal and diseased tissues, and the correlations between them are critical for clinical applications of conductivity (σ) and permittivity (ε); however, these correlations remain unknown. This study aimed to investigate potential correlations between electrical characteristics and biomarkers of breast cancer cells (BCC). Changes in σ and ε of different components in suspensions of normal cells and BCC were analyzed in the range of 200 kHz–5 MHz. Pearson's correlation coefficient heatmap was used to investigate the correlation between σ and ε of the cell suspensions at different stages and biomarkers of cell growth and microenvironment. σ and ε of the cell suspensions closely resembled those of tissues. Further, the correlations between Na+/H+ exchanger 1 and ε and σ of cell suspensions were extremely significant among all biomarkers (pε < 0.001; pσ < 0.001). There were significant positive correlations between cell proliferation biomarkers and ε and σ of cell suspensions (pε/σ < 0.05). The microenvironment may be crucial in the testing of cellular electrical properties. ε and σ are potential parameters to characterize the development of breast cancer.Yang WangYing LiJie HuangYan ZhangRen MaShunqi ZhangTao YinShangmei LiuYan SongZhipeng LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Wang Ying Li Jie Huang Yan Zhang Ren Ma Shunqi Zhang Tao Yin Shangmei Liu Yan Song Zhipeng Liu Correlation between electrical characteristics and biomarkers in breast cancer cells
description	Abstract Both electrical properties and biomarkers of biological tissues can be used to distinguish between normal and diseased tissues, and the correlations between them are critical for clinical applications of conductivity (σ) and permittivity (ε); however, these correlations remain unknown. This study aimed to investigate potential correlations between electrical characteristics and biomarkers of breast cancer cells (BCC). Changes in σ and ε of different components in suspensions of normal cells and BCC were analyzed in the range of 200 kHz–5 MHz. Pearson's correlation coefficient heatmap was used to investigate the correlation between σ and ε of the cell suspensions at different stages and biomarkers of cell growth and microenvironment. σ and ε of the cell suspensions closely resembled those of tissues. Further, the correlations between Na+/H+ exchanger 1 and ε and σ of cell suspensions were extremely significant among all biomarkers (pε < 0.001; pσ < 0.001). There were significant positive correlations between cell proliferation biomarkers and ε and σ of cell suspensions (pε/σ < 0.05). The microenvironment may be crucial in the testing of cellular electrical properties. ε and σ are potential parameters to characterize the development of breast cancer.
format	article
author	Yang Wang Ying Li Jie Huang Yan Zhang Ren Ma Shunqi Zhang Tao Yin Shangmei Liu Yan Song Zhipeng Liu
author_facet	Yang Wang Ying Li Jie Huang Yan Zhang Ren Ma Shunqi Zhang Tao Yin Shangmei Liu Yan Song Zhipeng Liu
author_sort	Yang Wang
title	Correlation between electrical characteristics and biomarkers in breast cancer cells
title_short	Correlation between electrical characteristics and biomarkers in breast cancer cells
title_full	Correlation between electrical characteristics and biomarkers in breast cancer cells
title_fullStr	Correlation between electrical characteristics and biomarkers in breast cancer cells
title_full_unstemmed	Correlation between electrical characteristics and biomarkers in breast cancer cells
title_sort	correlation between electrical characteristics and biomarkers in breast cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c22fc53d3f34a668d3837e2d390bea9
work_keys_str_mv	AT yangwang correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT yingli correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT jiehuang correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT yanzhang correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT renma correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT shunqizhang correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT taoyin correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT shangmeiliu correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT yansong correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells AT zhipengliu correlationbetweenelectricalcharacteristicsandbiomarkersinbreastcancercells
_version_	1718384588585172992

Correlation between electrical characteristics and biomarkers in breast cancer cells

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