Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

Abstract The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation a...

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Autores principales:	Bartłomiej Paleczny, Rafał Seredyński, Małgorzata Wyciszkiewicz, Adrianna Nowicka-Czudak, Wojciech Łopusiewicz, Dorota Adamiec, Szczepan Wiecha, Dariusz Mroczek, Paweł Chmura, Marek Konefał, Krzysztof Maćkała, Krystyna Chromik, Damian Pawlik, Marcin Andrzejewski, Jan Chmura, Piotr Ponikowski, Beata Ponikowska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c24391e4f7049d0bcc0bbb98010fb50
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spelling	oai:doaj.org-article:3c24391e4f7049d0bcc0bbb98010fb502021-12-02T15:55:08ZLow ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men10.1038/s41598-021-89766-42045-2322https://doaj.org/article/3c24391e4f7049d0bcc0bbb98010fb502021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89766-4https://doaj.org/toc/2045-2322Abstract The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r = − 0.53, r = 0.67, respectively) and pre-race BHT (r = − 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r = − 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.Bartłomiej PalecznyRafał SeredyńskiMałgorzata WyciszkiewiczAdrianna Nowicka-CzudakWojciech ŁopusiewiczDorota AdamiecSzczepan WiechaDariusz MroczekPaweł ChmuraMarek KonefałKrzysztof MaćkałaKrystyna ChromikDamian PawlikMarcin AndrzejewskiJan ChmuraPiotr PonikowskiBeata PonikowskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bartłomiej Paleczny Rafał Seredyński Małgorzata Wyciszkiewicz Adrianna Nowicka-Czudak Wojciech Łopusiewicz Dorota Adamiec Szczepan Wiecha Dariusz Mroczek Paweł Chmura Marek Konefał Krzysztof Maćkała Krystyna Chromik Damian Pawlik Marcin Andrzejewski Jan Chmura Piotr Ponikowski Beata Ponikowska Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
description	Abstract The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r = − 0.53, r = 0.67, respectively) and pre-race BHT (r = − 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r = − 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.
format	article
author	Bartłomiej Paleczny Rafał Seredyński Małgorzata Wyciszkiewicz Adrianna Nowicka-Czudak Wojciech Łopusiewicz Dorota Adamiec Szczepan Wiecha Dariusz Mroczek Paweł Chmura Marek Konefał Krzysztof Maćkała Krystyna Chromik Damian Pawlik Marcin Andrzejewski Jan Chmura Piotr Ponikowski Beata Ponikowska
author_facet	Bartłomiej Paleczny Rafał Seredyński Małgorzata Wyciszkiewicz Adrianna Nowicka-Czudak Wojciech Łopusiewicz Dorota Adamiec Szczepan Wiecha Dariusz Mroczek Paweł Chmura Marek Konefał Krzysztof Maćkała Krystyna Chromik Damian Pawlik Marcin Andrzejewski Jan Chmura Piotr Ponikowski Beata Ponikowska
author_sort	Bartłomiej Paleczny
title	Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
title_short	Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
title_full	Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
title_fullStr	Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
title_full_unstemmed	Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
title_sort	low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c24391e4f7049d0bcc0bbb98010fb50
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Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

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