Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

Abstract Positive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) has benefits on the onset of epilepsy and epileptogenesis. However, it’s unclear whether LFS can retard the...

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Autores principales:	Yifang Kuang, Cenglin Xu, Yinxi Zhang, Yi Wang, Xiaohua Wu, Ying Wang, Yao Liu, Kai Zhong, Hui Cheng, Yi Guo, Shuang Wang, Meiping Ding, Zhong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c275ac488914375aa927d56bfaa8e80
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spelling	oai:doaj.org-article:3c275ac488914375aa927d56bfaa8e802021-12-02T15:06:18ZLow-frequency stimulation of the primary focus retards positive transfer of secondary focus10.1038/s41598-017-00479-z2045-2322https://doaj.org/article/3c275ac488914375aa927d56bfaa8e802017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00479-zhttps://doaj.org/toc/2045-2322Abstract Positive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) has benefits on the onset of epilepsy and epileptogenesis. However, it’s unclear whether LFS can retard the PTS in epilepsy. Here we found that PTS at both contralateral amygdala and ipsilateral hippocampus were promoted after the primary focus was fully kindled in rat kindling model. The promotion of PTS at the mirror focus started when the primary kindling acquisition reached focal seizures. LFS retarded the promotion of PTS when it was applied at the primary focus during its kindling acquisition, while it only slightly retarded the promotion of PTS when applied after generalized seizures. Meanwhile, we found the expression of potassium chloride cotransporter 2 (KCC2) decreased during PTS, and LFS reversed this. Further, the decreased expression of KCC2 was verified in patients with PTS. These findings suggest that LFS may be a potential therapeutic approach for PTS in epilepsy.Yifang KuangCenglin XuYinxi ZhangYi WangXiaohua WuYing WangYao LiuKai ZhongHui ChengYi GuoShuang WangMeiping DingZhong ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yifang Kuang Cenglin Xu Yinxi Zhang Yi Wang Xiaohua Wu Ying Wang Yao Liu Kai Zhong Hui Cheng Yi Guo Shuang Wang Meiping Ding Zhong Chen Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
description	Abstract Positive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) has benefits on the onset of epilepsy and epileptogenesis. However, it’s unclear whether LFS can retard the PTS in epilepsy. Here we found that PTS at both contralateral amygdala and ipsilateral hippocampus were promoted after the primary focus was fully kindled in rat kindling model. The promotion of PTS at the mirror focus started when the primary kindling acquisition reached focal seizures. LFS retarded the promotion of PTS when it was applied at the primary focus during its kindling acquisition, while it only slightly retarded the promotion of PTS when applied after generalized seizures. Meanwhile, we found the expression of potassium chloride cotransporter 2 (KCC2) decreased during PTS, and LFS reversed this. Further, the decreased expression of KCC2 was verified in patients with PTS. These findings suggest that LFS may be a potential therapeutic approach for PTS in epilepsy.
format	article
author	Yifang Kuang Cenglin Xu Yinxi Zhang Yi Wang Xiaohua Wu Ying Wang Yao Liu Kai Zhong Hui Cheng Yi Guo Shuang Wang Meiping Ding Zhong Chen
author_facet	Yifang Kuang Cenglin Xu Yinxi Zhang Yi Wang Xiaohua Wu Ying Wang Yao Liu Kai Zhong Hui Cheng Yi Guo Shuang Wang Meiping Ding Zhong Chen
author_sort	Yifang Kuang
title	Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
title_short	Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
title_full	Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
title_fullStr	Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
title_full_unstemmed	Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
title_sort	low-frequency stimulation of the primary focus retards positive transfer of secondary focus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3c275ac488914375aa927d56bfaa8e80
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Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

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