Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon

T helper 2 (Th2) cell responses are essential for immunity against parasites, but how Th2 response is modulated in the gut is still unclear. Here the authors show that distinct dendritic cell subsets distinguishable by CD11b, CD103 and IRF4 function in the small intestine or colon to promote Th2 res...

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Autores principales: Johannes U. Mayer, Mimoza Demiri, William W. Agace, Andrew S. MacDonald, Marcus Svensson-Frej, Simon W. Milling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3c27826cbd534f9586aaa3ade5f87475
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Sumario:T helper 2 (Th2) cell responses are essential for immunity against parasites, but how Th2 response is modulated in the gut is still unclear. Here the authors show that distinct dendritic cell subsets distinguishable by CD11b, CD103 and IRF4 function in the small intestine or colon to promote Th2 responses.