Post-zygotic and inter-individual structural genetic variation in a presumptive enhancer element of the locus between the IL10Rβ and IFNAR1 genes.

Post-zygotic and inter-individual structural genetic variation in a presumptive enhancer element of the locus between the IL10Rβ and IFNAR1 genes.

Although historically considered as junk-DNA, tandemly repeated sequence motifs can affect human phenotype. For example, variable number tandem repeats (VNTR) with embedded enhancers have been shown to regulate gene transcription. The post-zygotic variation is the presence of genetically distinct po...

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Autores principales: Hamid Reza Razzaghian, Lars A Forsberg, Kancherla Reddy Prakash, Szymon Przerada, Hanna Paprocka, Anna Zywicka, Maxwell P Westerman, Nancy L Pedersen, Terrance P O'Hanlon, Lisa G Rider, Frederick W Miller, Ewa Srutek, Michal Jankowski, Wojciech Zegarski, Arkadiusz Piotrowski, Devin Absher, Jan P Dumanski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3c2a13cdb2a84d8d9cc4928f081f6af1
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