Looking for Needles in the Plasmodial Haystack

ABSTRACT Plasmodium falciparum malaria remains a globally leading infectious disease problem. Despite decades of intense investigation, an efficacious and practical vaccine offering durable protection to people living in areas with transmission of malaria parasites remains an elusive goal. Our fragm...

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Auteur principal:	Lars Hviid
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2019
Sujets:	Plasmodium falciparum antibodies antigens malaria Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/3c2bbf5d731c4da0998946e8b0f4600f
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spelling	oai:doaj.org-article:3c2bbf5d731c4da0998946e8b0f4600f2021-11-15T15:22:22ZLooking for Needles in the Plasmodial Haystack10.1128/mSphere.00146-192379-5042https://doaj.org/article/3c2bbf5d731c4da0998946e8b0f4600f2019-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00146-19https://doaj.org/toc/2379-5042ABSTRACT Plasmodium falciparum malaria remains a globally leading infectious disease problem. Despite decades of intense investigation, an efficacious and practical vaccine offering durable protection to people living in areas with transmission of malaria parasites remains an elusive goal. Our fragmentary understanding of the mechanisms of protective immunity to the disease is a major obstacle, and the almost complete focus on a very small subset of P. falciparum proteins as vaccine candidates has left most parasite antigens essentially unexplored as targets of acquired immunity. However, with the protein microarray technology, it is now possible to interrogate the entire parasite proteome for new vaccine candidates and for markers of parasite exposure. Recent mSphere papers describe the results of such research.Lars HviidAmerican Society for MicrobiologyarticlePlasmodium falciparumantibodiesantigensmalariaMicrobiologyQR1-502ENmSphere, Vol 4, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plasmodium falciparum antibodies antigens malaria Microbiology QR1-502
spellingShingle	Plasmodium falciparum antibodies antigens malaria Microbiology QR1-502 Lars Hviid Looking for Needles in the Plasmodial Haystack
description	ABSTRACT Plasmodium falciparum malaria remains a globally leading infectious disease problem. Despite decades of intense investigation, an efficacious and practical vaccine offering durable protection to people living in areas with transmission of malaria parasites remains an elusive goal. Our fragmentary understanding of the mechanisms of protective immunity to the disease is a major obstacle, and the almost complete focus on a very small subset of P. falciparum proteins as vaccine candidates has left most parasite antigens essentially unexplored as targets of acquired immunity. However, with the protein microarray technology, it is now possible to interrogate the entire parasite proteome for new vaccine candidates and for markers of parasite exposure. Recent mSphere papers describe the results of such research.
format	article
author	Lars Hviid
author_facet	Lars Hviid
author_sort	Lars Hviid
title	Looking for Needles in the Plasmodial Haystack
title_short	Looking for Needles in the Plasmodial Haystack
title_full	Looking for Needles in the Plasmodial Haystack
title_fullStr	Looking for Needles in the Plasmodial Haystack
title_full_unstemmed	Looking for Needles in the Plasmodial Haystack
title_sort	looking for needles in the plasmodial haystack
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/3c2bbf5d731c4da0998946e8b0f4600f
work_keys_str_mv	AT larshviid lookingforneedlesintheplasmodialhaystack
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Looking for Needles in the Plasmodial Haystack

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