TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer dev...

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Autores principales:	Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c2d0b0fc6204a1b837bc243ca4ab438
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spelling	oai:doaj.org-article:3c2d0b0fc6204a1b837bc243ca4ab4382021-12-02T14:39:46ZTRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis10.1038/s41467-018-05796-z2041-1723https://doaj.org/article/3c2d0b0fc6204a1b837bc243ca4ab4382018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05796-zhttps://doaj.org/toc/2041-1723Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer development.Hong-Xia ZhangZhi-Sheng XuHen LinMi LiTian XiaKaisa CuiSu-Yun WangYoujun LiHong-Bing ShuYan-Yi WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
description	Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer development.
format	article
author	Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang
author_facet	Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang
author_sort	Hong-Xia Zhang
title	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_short	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_full	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_fullStr	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_full_unstemmed	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_sort	trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c2d0b0fc6204a1b837bc243ca4ab438
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TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

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