TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer dev...

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Autores principales: Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/3c2d0b0fc6204a1b837bc243ca4ab438
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