Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

The mechanism of DNA gyrase inhibitor stabilization of single-strand DNA cleavage breaks by DNA gyrase has been hypothetical. Here, the authors show experimental evidence of the mechanism using a library of inhibitors with improved binding and employ crystal analysis to show bifurcated halogen bondi...

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Autores principales:	Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c2f423c4f2146d28e6a3bf66952a1ce
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spelling	oai:doaj.org-article:3c2f423c4f2146d28e6a3bf66952a1ce2021-12-02T11:45:56ZPotent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds10.1038/s41467-020-20405-82041-1723https://doaj.org/article/3c2f423c4f2146d28e6a3bf66952a1ce2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20405-8https://doaj.org/toc/2041-1723The mechanism of DNA gyrase inhibitor stabilization of single-strand DNA cleavage breaks by DNA gyrase has been hypothetical. Here, the authors show experimental evidence of the mechanism using a library of inhibitors with improved binding and employ crystal analysis to show bifurcated halogen bonding.Anja KolaričThomas GermeMartina HrastClare E. M. StevensonDavid M. LawsonNicolas P. BurtonJudit VörösAnthony MaxwellNikola MinovskiMarko AnderluhNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anja Kolarič Thomas Germe Martina Hrast Clare E. M. Stevenson David M. Lawson Nicolas P. Burton Judit Vörös Anthony Maxwell Nikola Minovski Marko Anderluh Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
description	The mechanism of DNA gyrase inhibitor stabilization of single-strand DNA cleavage breaks by DNA gyrase has been hypothetical. Here, the authors show experimental evidence of the mechanism using a library of inhibitors with improved binding and employ crystal analysis to show bifurcated halogen bonding.
format	article
author	Anja Kolarič Thomas Germe Martina Hrast Clare E. M. Stevenson David M. Lawson Nicolas P. Burton Judit Vörös Anthony Maxwell Nikola Minovski Marko Anderluh
author_facet	Anja Kolarič Thomas Germe Martina Hrast Clare E. M. Stevenson David M. Lawson Nicolas P. Burton Judit Vörös Anthony Maxwell Nikola Minovski Marko Anderluh
author_sort	Anja Kolarič
title	Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
title_short	Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
title_full	Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
title_fullStr	Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
title_full_unstemmed	Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
title_sort	potent dna gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c2f423c4f2146d28e6a3bf66952a1ce
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Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

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