Increased phosphorylation of vimentin in noninfiltrative meningiomas.

<h4>Background</h4>Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas.<h4&g...

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Autores principales:	Ali Bouamrani, Claire Ramus, Emmanuel Gay, Laurent Pelletier, Myriam Cubizolles, Sabine Brugière, Didier Wion, François Berger, Jean-Paul Issartel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c2f47059bd447df87fa28acbc6599f7
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spelling	oai:doaj.org-article:3c2f47059bd447df87fa28acbc6599f72021-11-25T06:25:49ZIncreased phosphorylation of vimentin in noninfiltrative meningiomas.1932-620310.1371/journal.pone.0009238https://doaj.org/article/3c2f47059bd447df87fa28acbc6599f72010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20169076/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas.<h4>Methodology/principal findings</h4>Protein lysates of 64 different tissue samples (including two brain-invasive and 32 infiltrative tumors) were submitted to SELDI-TOF mass spectrometric analysis. Mass profiles were used to build up both unsupervised and supervised hierarchical clustering. One marker was found at high levels in noninvasive and noninfiltrative tumors and appeared to be a discriminative marker for clustering infiltrative and/or invasive meningiomas versus noninvasive meningiomas in two distinct subsets. Sensitivity and specificity were 86.7% and 100%, respectively. This marker was purified and identified as a multiphosphorylated form of vimentin, a cytoskeletal protein expressed in meningiomas.<h4>Conclusions/significance</h4>Specific forms of vimentin can be surrogate molecular indicators of the invasive/infiltrative phenotype in tumors.Ali BouamraniClaire RamusEmmanuel GayLaurent PelletierMyriam CubizollesSabine BrugièreDidier WionFrançois BergerJean-Paul IssartelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9238 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Bouamrani Claire Ramus Emmanuel Gay Laurent Pelletier Myriam Cubizolles Sabine Brugière Didier Wion François Berger Jean-Paul Issartel Increased phosphorylation of vimentin in noninfiltrative meningiomas.
description	<h4>Background</h4>Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas.<h4>Methodology/principal findings</h4>Protein lysates of 64 different tissue samples (including two brain-invasive and 32 infiltrative tumors) were submitted to SELDI-TOF mass spectrometric analysis. Mass profiles were used to build up both unsupervised and supervised hierarchical clustering. One marker was found at high levels in noninvasive and noninfiltrative tumors and appeared to be a discriminative marker for clustering infiltrative and/or invasive meningiomas versus noninvasive meningiomas in two distinct subsets. Sensitivity and specificity were 86.7% and 100%, respectively. This marker was purified and identified as a multiphosphorylated form of vimentin, a cytoskeletal protein expressed in meningiomas.<h4>Conclusions/significance</h4>Specific forms of vimentin can be surrogate molecular indicators of the invasive/infiltrative phenotype in tumors.
format	article
author	Ali Bouamrani Claire Ramus Emmanuel Gay Laurent Pelletier Myriam Cubizolles Sabine Brugière Didier Wion François Berger Jean-Paul Issartel
author_facet	Ali Bouamrani Claire Ramus Emmanuel Gay Laurent Pelletier Myriam Cubizolles Sabine Brugière Didier Wion François Berger Jean-Paul Issartel
author_sort	Ali Bouamrani
title	Increased phosphorylation of vimentin in noninfiltrative meningiomas.
title_short	Increased phosphorylation of vimentin in noninfiltrative meningiomas.
title_full	Increased phosphorylation of vimentin in noninfiltrative meningiomas.
title_fullStr	Increased phosphorylation of vimentin in noninfiltrative meningiomas.
title_full_unstemmed	Increased phosphorylation of vimentin in noninfiltrative meningiomas.
title_sort	increased phosphorylation of vimentin in noninfiltrative meningiomas.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/3c2f47059bd447df87fa28acbc6599f7
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Increased phosphorylation of vimentin in noninfiltrative meningiomas.

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