Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 media...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3c2f87ae1c244f13b1b1ad0a9daad872
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3c2f87ae1c244f13b1b1ad0a9daad872
record_format dspace
spelling oai:doaj.org-article:3c2f87ae1c244f13b1b1ad0a9daad8722021-12-02T14:16:13ZNiche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-110.1038/s41467-020-20801-02041-1723https://doaj.org/article/3c2f87ae1c244f13b1b1ad0a9daad8722021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20801-0https://doaj.org/toc/2041-1723Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 mediated HSC self-renewal.Simon RendersArthur Flohr SvendsenJasper PantenNicolas RamaMaria MaryanovichPia SommerkampLuisa LadelAnna Rita RedavidBenjamin GibertSeka LazareBenjamin DucarougeKatharina SchönbergerAndreas NarrManon TourbezBertien Dethmers-AusemaErik ZwartAgnes Hotz-WagenblattDachuan ZhangClaudia KornPetra ZeisbergerAdriana PrzybyllaMarkus SohnSimon Mendez-FerrerMathias HeikenwälderMaik BruneDaniel KlimmeckLeonid BystrykhPaul S. FrenettePatrick MehlenGerald de HaanNina Cabezas-WallscheidAndreas TrumppNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Simon Renders
Arthur Flohr Svendsen
Jasper Panten
Nicolas Rama
Maria Maryanovich
Pia Sommerkamp
Luisa Ladel
Anna Rita Redavid
Benjamin Gibert
Seka Lazare
Benjamin Ducarouge
Katharina Schönberger
Andreas Narr
Manon Tourbez
Bertien Dethmers-Ausema
Erik Zwart
Agnes Hotz-Wagenblatt
Dachuan Zhang
Claudia Korn
Petra Zeisberger
Adriana Przybylla
Markus Sohn
Simon Mendez-Ferrer
Mathias Heikenwälder
Maik Brune
Daniel Klimmeck
Leonid Bystrykh
Paul S. Frenette
Patrick Mehlen
Gerald de Haan
Nina Cabezas-Wallscheid
Andreas Trumpp
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
description Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 mediated HSC self-renewal.
format article
author Simon Renders
Arthur Flohr Svendsen
Jasper Panten
Nicolas Rama
Maria Maryanovich
Pia Sommerkamp
Luisa Ladel
Anna Rita Redavid
Benjamin Gibert
Seka Lazare
Benjamin Ducarouge
Katharina Schönberger
Andreas Narr
Manon Tourbez
Bertien Dethmers-Ausema
Erik Zwart
Agnes Hotz-Wagenblatt
Dachuan Zhang
Claudia Korn
Petra Zeisberger
Adriana Przybylla
Markus Sohn
Simon Mendez-Ferrer
Mathias Heikenwälder
Maik Brune
Daniel Klimmeck
Leonid Bystrykh
Paul S. Frenette
Patrick Mehlen
Gerald de Haan
Nina Cabezas-Wallscheid
Andreas Trumpp
author_facet Simon Renders
Arthur Flohr Svendsen
Jasper Panten
Nicolas Rama
Maria Maryanovich
Pia Sommerkamp
Luisa Ladel
Anna Rita Redavid
Benjamin Gibert
Seka Lazare
Benjamin Ducarouge
Katharina Schönberger
Andreas Narr
Manon Tourbez
Bertien Dethmers-Ausema
Erik Zwart
Agnes Hotz-Wagenblatt
Dachuan Zhang
Claudia Korn
Petra Zeisberger
Adriana Przybylla
Markus Sohn
Simon Mendez-Ferrer
Mathias Heikenwälder
Maik Brune
Daniel Klimmeck
Leonid Bystrykh
Paul S. Frenette
Patrick Mehlen
Gerald de Haan
Nina Cabezas-Wallscheid
Andreas Trumpp
author_sort Simon Renders
title Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
title_short Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
title_full Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
title_fullStr Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
title_full_unstemmed Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
title_sort niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3c2f87ae1c244f13b1b1ad0a9daad872
work_keys_str_mv AT simonrenders nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT arthurflohrsvendsen nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT jasperpanten nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT nicolasrama nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT mariamaryanovich nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT piasommerkamp nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT luisaladel nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT annaritaredavid nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT benjamingibert nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT sekalazare nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT benjaminducarouge nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT katharinaschonberger nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT andreasnarr nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT manontourbez nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT bertiendethmersausema nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT erikzwart nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT agneshotzwagenblatt nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT dachuanzhang nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT claudiakorn nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT petrazeisberger nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT adrianaprzybylla nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT markussohn nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT simonmendezferrer nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT mathiasheikenwalder nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT maikbrune nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT danielklimmeck nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT leonidbystrykh nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT paulsfrenette nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT patrickmehlen nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT geralddehaan nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT ninacabezaswallscheid nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
AT andreastrumpp nichederivednetrin1regulateshematopoieticstemcelldormancyviaitsreceptorneogenin1
_version_ 1718391719430455296

Ejemplares similares