Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.

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Autores principales:	Ming Chen, Lixin Wan, Jiangwen Zhang, Jinfang Zhang, Lourdes Mendez, John G. Clohessy, Kelsey Berry, Joshua Victor, Qing Yin, Yuan Zhu, Wenyi Wei, Pier Paolo Pandolfi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c35271d6beb405c951ac4056c1c2de6
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spelling	oai:doaj.org-article:3c35271d6beb405c951ac4056c1c2de62021-12-02T14:40:43ZDeregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism10.1038/s41467-017-02272-y2041-1723https://doaj.org/article/3c35271d6beb405c951ac4056c1c2de62018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02272-yhttps://doaj.org/toc/2041-1723Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.Ming ChenLixin WanJiangwen ZhangJinfang ZhangLourdes MendezJohn G. ClohessyKelsey BerryJoshua VictorQing YinYuan ZhuWenyi WeiPier Paolo PandolfiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
description	Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.
format	article
author	Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi
author_facet	Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi
author_sort	Ming Chen
title	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_short	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_full	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_fullStr	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_full_unstemmed	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_sort	deregulated pp1α phosphatase activity towards mapk activation is antagonized by a tumor suppressive failsafe mechanism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3c35271d6beb405c951ac4056c1c2de6
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Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

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