Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells

Saravanan Govindaraju,1,* Arivazhagan Roshini,2,* Min-Ho Lee,3 Kyusik Yun11Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea; 2Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 3School of Inte...

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Autores principales:	Govindaraju S, Roshini A, Lee MH, Yun K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Gold cluster Flavonoids Fluorescent Property Anticancer Activity Would Healing. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3c36f19e2a0444989c0ab7a46c9cdcb3
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spelling	oai:doaj.org-article:3c36f19e2a0444989c0ab7a46c9cdcb32021-12-02T06:36:31ZKaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells1178-2013https://doaj.org/article/3c36f19e2a0444989c0ab7a46c9cdcb32019-07-01T00:00:00Zhttps://www.dovepress.com/kaempferol-conjugated-gold-nanoclusters-enabled-efficient-for-anticanc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Saravanan Govindaraju,1,* Arivazhagan Roshini,2,* Min-Ho Lee,3 Kyusik Yun11Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea; 2Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 3School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea*These authors contributed equally to this workBackground: Kaempferol (K) is a recognized anticancer drug that can conjugate with small-size gold nanoclusters (AuNCs).Materials and methods: K-AuNCs were synthesized and their use as an anticancer drug was explored using A549 lung cancer cells. Colony formation and cell migration assays were carried out. The morphology of the K-AuNCs treated A549 cells was explored using bio-atomic force microscopy.Results: The K-AuNCs were 1-3 nm in diameter and emitted strong fluorescent at 650 nm following excitation at 550 nm. The stretching and bending nature of the K-AuNCs were analyzed by the Fourier transform infrared spectroscopy. The presence of kaempferol in the AuNCs were confirmed by the PL spectroscopy.Conclusion: The synthesized K-AuNCs mainly targeted and damaged the nuclei of the cancer cells. This composite nanocluster was less toxicity to the normal human cell and higher toxicity to the A549 lunch cancer cell and these material is potential for anticancer drug delivery and bio imaging applications.Keywords: gold cluster, fluorescent property, biocompatible, flavonoids, anticancer activityGovindaraju SRoshini ALee MHYun KDove Medical PressarticleGold clusterFlavonoidsFluorescent PropertyAnticancer ActivityWould Healing.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5147-5157 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold cluster Flavonoids Fluorescent Property Anticancer Activity Would Healing. Medicine (General) R5-920
spellingShingle	Gold cluster Flavonoids Fluorescent Property Anticancer Activity Would Healing. Medicine (General) R5-920 Govindaraju S Roshini A Lee MH Yun K Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
description	Saravanan Govindaraju,1,* Arivazhagan Roshini,2,* Min-Ho Lee,3 Kyusik Yun11Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea; 2Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 3School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea*These authors contributed equally to this workBackground: Kaempferol (K) is a recognized anticancer drug that can conjugate with small-size gold nanoclusters (AuNCs).Materials and methods: K-AuNCs were synthesized and their use as an anticancer drug was explored using A549 lung cancer cells. Colony formation and cell migration assays were carried out. The morphology of the K-AuNCs treated A549 cells was explored using bio-atomic force microscopy.Results: The K-AuNCs were 1-3 nm in diameter and emitted strong fluorescent at 650 nm following excitation at 550 nm. The stretching and bending nature of the K-AuNCs were analyzed by the Fourier transform infrared spectroscopy. The presence of kaempferol in the AuNCs were confirmed by the PL spectroscopy.Conclusion: The synthesized K-AuNCs mainly targeted and damaged the nuclei of the cancer cells. This composite nanocluster was less toxicity to the normal human cell and higher toxicity to the A549 lunch cancer cell and these material is potential for anticancer drug delivery and bio imaging applications.Keywords: gold cluster, fluorescent property, biocompatible, flavonoids, anticancer activity
format	article
author	Govindaraju S Roshini A Lee MH Yun K
author_facet	Govindaraju S Roshini A Lee MH Yun K
author_sort	Govindaraju S
title	Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
title_short	Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
title_full	Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
title_fullStr	Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
title_full_unstemmed	Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells
title_sort	kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to a549 lung cancer cells
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3c36f19e2a0444989c0ab7a46c9cdcb3
work_keys_str_mv	AT govindarajus kaempferolconjugatedgoldnanoclustersenabledefficientforanticancertherapeuticstoa549lungcancercells AT roshinia kaempferolconjugatedgoldnanoclustersenabledefficientforanticancertherapeuticstoa549lungcancercells AT leemh kaempferolconjugatedgoldnanoclustersenabledefficientforanticancertherapeuticstoa549lungcancercells AT yunk kaempferolconjugatedgoldnanoclustersenabledefficientforanticancertherapeuticstoa549lungcancercells
_version_	1718399808391086080

Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells

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