Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increased longevity.

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Autores principales:	Manish Chamoli, Anita Goyala, Syed Shamsh Tabrez, Atif Ahmed Siddiqui, Anupama Singh, Adam Antebi, Gordon J. Lithgow, Jennifer L. Watts, Arnab Mukhopadhyay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c37c1fd9a7048f1bb216609bd91f5e7
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spelling	oai:doaj.org-article:3c37c1fd9a7048f1bb216609bd91f5e72021-12-02T15:14:56ZPolyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction10.1038/s41467-020-18690-42041-1723https://doaj.org/article/3c37c1fd9a7048f1bb216609bd91f5e72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18690-4https://doaj.org/toc/2041-1723Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increased longevity.Manish ChamoliAnita GoyalaSyed Shamsh TabrezAtif Ahmed SiddiquiAnupama SinghAdam AntebiGordon J. LithgowJennifer L. WattsArnab MukhopadhyayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manish Chamoli Anita Goyala Syed Shamsh Tabrez Atif Ahmed Siddiqui Anupama Singh Adam Antebi Gordon J. Lithgow Jennifer L. Watts Arnab Mukhopadhyay Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
description	Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increased longevity.
format	article
author	Manish Chamoli Anita Goyala Syed Shamsh Tabrez Atif Ahmed Siddiqui Anupama Singh Adam Antebi Gordon J. Lithgow Jennifer L. Watts Arnab Mukhopadhyay
author_facet	Manish Chamoli Anita Goyala Syed Shamsh Tabrez Atif Ahmed Siddiqui Anupama Singh Adam Antebi Gordon J. Lithgow Jennifer L. Watts Arnab Mukhopadhyay
author_sort	Manish Chamoli
title	Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
title_short	Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
title_full	Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
title_fullStr	Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
title_full_unstemmed	Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
title_sort	polyunsaturated fatty acids and p38-mapk link metabolic reprogramming to cytoprotective gene expression during dietary restriction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c37c1fd9a7048f1bb216609bd91f5e7
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Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

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