Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.

Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potenti...

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Autores principales:	Choongseok Park, Leonid L Rubchinsky
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c3898b9064c4dc6831a53b91464d18c
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spelling	oai:doaj.org-article:3c3898b9064c4dc6831a53b91464d18c2021-11-18T08:04:33ZPotential mechanisms for imperfect synchronization in parkinsonian basal ganglia.1932-620310.1371/journal.pone.0051530https://doaj.org/article/3c3898b9064c4dc6831a53b91464d18c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284707/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony. We study the response of a bursting pallidal neuron to different patterns of synaptic input from subthalamic nucleus (STN) neuron. We show how external globus pallidus (GPe) neuron is sensitive to the phase of the input from the STN cell and can exhibit intermittent phase-locking with the input in the beta band. The temporal properties of this intermittent phase-locking show similarities to the intermittent synchronization observed in experiments. We also study the synchronization of GPe cells to synaptic input from the STN cell with dependence on the dopamine-modulated parameters. Earlier studies showed how the strengthening of dopamine-modulated coupling may lead to transitions from non-synchronized to partially synchronized dynamics, typical in Parkinson's disease. However, dopamine also affects the cellular properties of neurons. We show how the changes in firing patterns of STN neuron due to the lack of dopamine may lead to transition from a lower to a higher coherent state, roughly matching the synchrony levels observed in basal ganglia in normal and parkinsonian states. The intermittent nature of the neural beta band synchrony in Parkinson's disease is achieved in the model due to the interplay of the timing of STN input to pallidum and pallidal neuronal dynamics, resulting in sensitivity of pallidal output to the phase of the arriving STN input. Thus the mechanism considered here (the change in firing pattern of subthalamic neurons through the dopamine-induced change of membrane properties) may be one of the potential mechanisms responsible for the generation of the intermittent synchronization observed in Parkinson's disease.Choongseok ParkLeonid L RubchinskyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51530 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Choongseok Park Leonid L Rubchinsky Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
description	Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony. We study the response of a bursting pallidal neuron to different patterns of synaptic input from subthalamic nucleus (STN) neuron. We show how external globus pallidus (GPe) neuron is sensitive to the phase of the input from the STN cell and can exhibit intermittent phase-locking with the input in the beta band. The temporal properties of this intermittent phase-locking show similarities to the intermittent synchronization observed in experiments. We also study the synchronization of GPe cells to synaptic input from the STN cell with dependence on the dopamine-modulated parameters. Earlier studies showed how the strengthening of dopamine-modulated coupling may lead to transitions from non-synchronized to partially synchronized dynamics, typical in Parkinson's disease. However, dopamine also affects the cellular properties of neurons. We show how the changes in firing patterns of STN neuron due to the lack of dopamine may lead to transition from a lower to a higher coherent state, roughly matching the synchrony levels observed in basal ganglia in normal and parkinsonian states. The intermittent nature of the neural beta band synchrony in Parkinson's disease is achieved in the model due to the interplay of the timing of STN input to pallidum and pallidal neuronal dynamics, resulting in sensitivity of pallidal output to the phase of the arriving STN input. Thus the mechanism considered here (the change in firing pattern of subthalamic neurons through the dopamine-induced change of membrane properties) may be one of the potential mechanisms responsible for the generation of the intermittent synchronization observed in Parkinson's disease.
format	article
author	Choongseok Park Leonid L Rubchinsky
author_facet	Choongseok Park Leonid L Rubchinsky
author_sort	Choongseok Park
title	Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
title_short	Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
title_full	Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
title_fullStr	Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
title_full_unstemmed	Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
title_sort	potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3c3898b9064c4dc6831a53b91464d18c
work_keys_str_mv	AT choongseokpark potentialmechanismsforimperfectsynchronizationinparkinsonianbasalganglia AT leonidlrubchinsky potentialmechanismsforimperfectsynchronizationinparkinsonianbasalganglia
_version_	1718422222877491200

Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia.

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